# Multiplex Interaction Prediction on PINNACLE zero-shot

Source: [Multiplex Interaction Prediction on PINNACLE zero-shot](<https://www.sota2.com/research/sota/multiplex-interaction-prediction-on-pinnacle-zero-shot>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2026-03-10T07:50:28.192Z

Evaluation of model performance on predicting multiplex interactions using the PINNACLE dataset under zero-shot conditions, measured by AUROC, AUPRC, HS, and SA.

A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage.

| Scope | Recorded value |
| --- | --- |
| Task | multiplex interaction prediction |
| Dataset (including any stated split) | PINNACLE zero-shot |
| Metric | AUROC |
| Unit | PERCENT |
| Direction | Higher is better |
| Results loaded | 16 of 16 |
| Coverage | All results currently returned for this benchmark |

Evaluation settings may differ between results. The original papers and recorded configurations are needed to establish comparability. A shared metric name alone does not establish an identical protocol.

## Metrics

- [AUROC](<https://www.sota2.com/research/sota/multiplex-interaction-prediction-on-pinnacle-zero-shot.md?metric=AUROC>): Higher is better; unit: PERCENT.

- [AUPRC](<https://www.sota2.com/research/sota/multiplex-interaction-prediction-on-pinnacle-zero-shot.md?metric=AUPRC>): Higher is better; unit: PERCENT.

- [HS](<https://www.sota2.com/research/sota/multiplex-interaction-prediction-on-pinnacle-zero-shot.md?metric=HS>): Higher is better; unit: PERCENT.

- [SA](<https://www.sota2.com/research/sota/multiplex-interaction-prediction-on-pinnacle-zero-shot.md?metric=SA>): Higher is better; unit: PERCENT.

## Recorded results

| Method | AUROC | Result date | Report paper |
| --- | --- | --- | --- |
| CAZI-MBN | 81.2 | Not recorded | 69afa57c2d603e6de3e439b6 |
| xCAPT5 | 78.5 | Not recorded | 69afa57c2d603e6de3e439b6 |
| HDMI | 74.8 | Not recorded | 69afa57c2d603e6de3e439b6 |
| DMGI | 74.4 | Not recorded | 69afa57c2d603e6de3e439b6 |
| R-GCN | 73.3 | Not recorded | 69afa57c2d603e6de3e439b6 |
| MultiplexSAGE | 72.8 | Not recorded | 69afa57c2d603e6de3e439b6 |
| R-GAT | 72.6 | Not recorded | 69afa57c2d603e6de3e439b6 |
| PIPR | 72.1 | Not recorded | 69afa57c2d603e6de3e439b6 |
| XGB (LLM) | 71.9 | Not recorded | 69afa57c2d603e6de3e439b6 |
| MLP (LLM) | 71.4 | Not recorded | 69afa57c2d603e6de3e439b6 |
| Graph Transformer | 68.7 | Not recorded | 69afa57c2d603e6de3e439b6 |
| DGI | 67.4 | Not recorded | 69afa57c2d603e6de3e439b6 |
| GraphSAGE | 67.3 | Not recorded | 69afa57c2d603e6de3e439b6 |
| MLP | 65.2 | Not recorded | 69afa57c2d603e6de3e439b6 |
| GCN | 63.9 | Not recorded | 69afa57c2d603e6de3e439b6 |
| XGB | 62.6 | Not recorded | 69afa57c2d603e6de3e439b6 |

### CAZI-MBN

AUROC: 81.2. Result ID: 69afcc576dbb7075b957dd84.

[Reporting paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b6.md>)

[Method origin paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b6.md>)

Recorded evaluation configuration: {"Setting":"ZS"}. This record does not assert independent reproduction.

### xCAPT5

AUROC: 78.5. Result ID: 69afcc576dbb7075b957dd83.

[Reporting paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b6.md>)

Recorded evaluation configuration: {"Setting":"ZS"}. This record does not assert independent reproduction.

### HDMI

AUROC: 74.8. Result ID: 69afcc576dbb7075b957dd7f.

[Reporting paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b6.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa583a1e209131ce9ac7f5.md>)

Recorded evaluation configuration: {"Setting":"ZS"}. This record does not assert independent reproduction.

### DMGI

AUROC: 74.4. Result ID: 69afcc576dbb7075b957dd7e.

[Reporting paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b6.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa673c1e209131cea1514f.md>)

Recorded evaluation configuration: {"Setting":"ZS"}. This record does not assert independent reproduction.

### R-GCN

AUROC: 73.3. Result ID: 69afcc576dbb7075b957dd80.

[Reporting paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b6.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa63be1e209131cea00a2d.md>)

Recorded evaluation configuration: {"Setting":"ZS"}. This record does not assert independent reproduction.

### MultiplexSAGE

AUROC: 72.8. Result ID: 69afcc576dbb7075b957dd7d.

[Reporting paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b6.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa41f81e209131ce8fe9c2.md>)

Recorded evaluation configuration: {"Setting":"ZS"}. This record does not assert independent reproduction.

### R-GAT

AUROC: 72.6. Result ID: 69afcc576dbb7075b957dd81.

[Reporting paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b6.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa6ad11e209131cea2a844.md>)

Recorded evaluation configuration: {"Setting":"ZS"}. This record does not assert independent reproduction.

### PIPR

AUROC: 72.1. Result ID: 69afcc576dbb7075b957dd82.

[Reporting paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b6.md>)

Recorded evaluation configuration: {"Setting":"ZS"}. This record does not assert independent reproduction.

### XGB (LLM)

AUROC: 71.9. Result ID: 69afcc576dbb7075b957dd77.

[Reporting paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b6.md>)

Recorded evaluation configuration: {"Setting":"ZS"}. This record does not assert independent reproduction.

### MLP (LLM)

AUROC: 71.4. Result ID: 69afcc576dbb7075b957dd78.

[Reporting paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b6.md>)

Recorded evaluation configuration: {"Setting":"ZS"}. This record does not assert independent reproduction.

### Graph Transformer

AUROC: 68.7. Result ID: 69afcc576dbb7075b957dd7b.

[Reporting paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b6.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa69e81e209131cea24c42.md>)

Recorded evaluation configuration: {"Setting":"ZS"}. This record does not assert independent reproduction.

### DGI

AUROC: 67.4. Result ID: 69afcc576dbb7075b957dd7c.

[Reporting paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b6.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa556d1e209131ce993d7e.md>)

[Implementation](<https://github.com/PetarV-/DGI>)

Recorded evaluation configuration: {"Setting":"ZS"}. This record does not assert independent reproduction.

### GraphSAGE

AUROC: 67.3. Result ID: 69afcc576dbb7075b957dd7a.

[Reporting paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b6.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa64c31e209131cea0664e.md>)

[Implementation](<http://snap.stanford.edu/graphsage/>)

Recorded evaluation configuration: {"Setting":"ZS"}. This record does not assert independent reproduction.

### MLP

AUROC: 65.2. Result ID: 69afcc576dbb7075b957dd76.

[Reporting paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b6.md>)

Recorded evaluation configuration: {"Setting":"ZS"}. This record does not assert independent reproduction.

### GCN

AUROC: 63.9. Result ID: 69afcc576dbb7075b957dd79.

[Reporting paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b6.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa631d1e209131ce9fce45.md>)

[Implementation](<https://github.com/tkipf/gcn>)

Recorded evaluation configuration: {"Setting":"ZS"}. This record does not assert independent reproduction.

### XGB

AUROC: 62.6. Result ID: 69afcc576dbb7075b957dd75.

[Reporting paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b6.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa62821e209131ce9f9b56.md>)

[Implementation](<https://github.com/dmlc/xgboost>)

Recorded evaluation configuration: {"Setting":"ZS"}. This record does not assert independent reproduction.

Page 1 of 1. This is an index page, not the full collection.
