# Multi-specific antibody co-design on Split-B

Source: [Multi-specific antibody co-design on Split-B](<https://www.sota2.com/research/sota/multi-specific-antibody-co-design-on-split-b>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2026-03-10T07:44:26.108Z

Evaluation of models for multi-specific antibody co-design using the Split-B dataset, assessed by structural metrics like RMSD and predicted interface quality scores (design-ipTM).

A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage.

| Scope | Recorded value |
| --- | --- |
| Task | Multi-specific antibody co-design |
| Dataset (including any stated split) | Split-B |
| Metric | RMSD (Ag. A) |
| Unit | SCALAR |
| Direction | Lower is better |
| Results loaded | 7 of 7 |
| Coverage | All results currently returned for this benchmark |

Evaluation settings may differ between results. The original papers and recorded configurations are needed to establish comparability. A shared metric name alone does not establish an identical protocol.

## Metrics

- [RMSD (Ag. A)](<https://www.sota2.com/research/sota/multi-specific-antibody-co-design-on-split-b.md?metric=RMSD%20(Ag.%20A)>): Lower is better; unit: SCALAR.

- [RMSD (Ag. C)](<https://www.sota2.com/research/sota/multi-specific-antibody-co-design-on-split-b.md?metric=RMSD%20(Ag.%20C)>): Lower is better; unit: SCALAR.

- [RMSD (Avg.)](<https://www.sota2.com/research/sota/multi-specific-antibody-co-design-on-split-b.md?metric=RMSD%20(Avg.)>): Lower is better; unit: SCALAR.

- [design-ipTM (Ag. A)](<https://www.sota2.com/research/sota/multi-specific-antibody-co-design-on-split-b.md?metric=design-ipTM%20(Ag.%20A)>): Higher is better; unit: SCALAR.

- [design-ipTM (Ag. C)](<https://www.sota2.com/research/sota/multi-specific-antibody-co-design-on-split-b.md?metric=design-ipTM%20(Ag.%20C)>): Higher is better; unit: SCALAR.

- [design-ipTM (Avg.)](<https://www.sota2.com/research/sota/multi-specific-antibody-co-design-on-split-b.md?metric=design-ipTM%20(Avg.)>): Higher is better; unit: SCALAR.

## Recorded results

| Method | RMSD (Ag. A) | Result date | Report paper |
| --- | --- | --- | --- |
| ACG | 2.96 | Not recorded | 69afa57c2d603e6de3e439b3 |
| Consistent | 3.15 | Not recorded | 69afa57c2d603e6de3e439b3 |
| Single-target | 3.21 | Not recorded | 69afa57c2d603e6de3e439b3 |
| Greedy | 3.27 | Not recorded | 69afa57c2d603e6de3e439b3 |
| ACG | 3.75 | Not recorded | 69afa57c2d603e6de3e439b3 |
| Greedy | 3.87 | Not recorded | 69afa57c2d603e6de3e439b3 |
| Consistent | 4.22 | Not recorded | 69afa57c2d603e6de3e439b3 |

### ACG

RMSD (Ag. A): 2.96. Result ID: 69afcbc06dbb7075b957dae4.

[Reporting paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b3.md>)

[Method origin paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b3.md>)

Recorded evaluation configuration: {"Setup":"/w \[23\]"}. This record does not assert independent reproduction.

### Consistent

RMSD (Ag. A): 3.15. Result ID: 69afcbc06dbb7075b957dae2.

[Reporting paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b3.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa6e5a1e209131cea3f4ee.md>)

Recorded evaluation configuration: {"Setup":"/w \[23\]"}. This record does not assert independent reproduction.

### Single-target

RMSD (Ag. A): 3.21. Result ID: 69afcbc06dbb7075b957dade.

[Reporting paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b3.md>)

Recorded evaluation configuration: Not recorded. This record does not assert independent reproduction.

### Greedy

RMSD (Ag. A): 3.27. Result ID: 69afcbc06dbb7075b957dae0.

[Reporting paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b3.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa6ee51e209131cea42b2d.md>)

Recorded evaluation configuration: {"Setup":"/w \[23\]"}. This record does not assert independent reproduction.

### ACG

RMSD (Ag. A): 3.75. Result ID: 69afcbc06dbb7075b957dae3.

[Reporting paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b3.md>)

[Method origin paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b3.md>)

Recorded evaluation configuration: {"Setup":"\[9\]"}. This record does not assert independent reproduction.

### Greedy

RMSD (Ag. A): 3.87. Result ID: 69afcbc06dbb7075b957dadf.

[Reporting paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b3.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa6ee51e209131cea42b2d.md>)

Recorded evaluation configuration: {"Setup":"\[9\]"}. This record does not assert independent reproduction.

### Consistent

RMSD (Ag. A): 4.22. Result ID: 69afcbc06dbb7075b957dae1.

[Reporting paper](<https://www.sota2.com/research/paper/69afa57c2d603e6de3e439b3.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa6e5a1e209131cea3f4ee.md>)

Recorded evaluation configuration: {"Setup":"\[20\]"}. This record does not assert independent reproduction.

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