# Multi-objective Drug Discovery on c-MET MET\_HUMAN

Source: [Multi-objective Drug Discovery on c-MET MET\_HUMAN](<https://www.sota2.com/research/sota/multi-objective-drug-discovery-on-c-met-met_human>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2026-05-14T07:35:15.040Z

Evaluation of models performing multi-objective drug discovery using the c-MET MET\_HUMAN dataset, measured by Binding Affinity (BA), False Alarm Rate (FA), and Hitting Value (HV).

A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage.

| Scope | Recorded value |
| --- | --- |
| Task | Multi-objective Drug Discovery |
| Dataset (including any stated split) | c-MET MET\_HUMAN |
| Metric | Binding Affinity (BA) |
| Unit | SCALAR |
| Direction | Lower is better |
| Results loaded | 8 of 8 |
| Coverage | All results currently returned for this benchmark |

Evaluation settings may differ between results. The original papers and recorded configurations are needed to establish comparability. A shared metric name alone does not establish an identical protocol.

## Metrics

- [Binding Affinity (BA)](<https://www.sota2.com/research/sota/multi-objective-drug-discovery-on-c-met-met_human.md?metric=Binding%20Affinity%20(BA)>): Lower is better; unit: SCALAR.

- [False Alarm Rate (FA)](<https://www.sota2.com/research/sota/multi-objective-drug-discovery-on-c-met-met_human.md?metric=False%20Alarm%20Rate%20(FA)>): Lower is better; unit: SCALAR.

- [Hitting Value (HV)](<https://www.sota2.com/research/sota/multi-objective-drug-discovery-on-c-met-met_human.md?metric=Hitting%20Value%20(HV)>): Higher is better; unit: PERCENT.

## Recorded results

| Method | Binding Affinity (BA) | Result date | Report paper |
| --- | --- | --- | --- |
| MOLLEO | 10.15 | Not recorded | 6a05571cdbc836b87d828d12 |
| ShinkaEvolve | 10.17 | Not recorded | 6a05571cdbc836b87d828d12 |
| Graph-GA | 10.21 | Not recorded | 6a05571cdbc836b87d828d12 |
| PAFlow | 10.63 | Not recorded | 6a05571cdbc836b87d828d12 |
| ToolMol | 11 | Not recorded | 6a05571cdbc836b87d828d12 |
| ShinkaEvolve | 11.08 | Not recorded | 6a05571cdbc836b87d828d12 |
| Pocket2Mol | 11.27 | Not recorded | 6a05571cdbc836b87d828d12 |
| TAGMol | 11.45 | Not recorded | 6a05571cdbc836b87d828d12 |

### MOLLEO

Binding Affinity (BA): 10.15. Result ID: 6a057a7c47f34ce924ec1fd3.

[Reporting paper](<https://www.sota2.com/research/paper/6a05571cdbc836b87d828d12.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa49911e209131ce938018.md>)

Recorded evaluation configuration: {"Guidance Strategy":"Affinity feedback","Seeded Runs":"5","Oracle budget":"1000 evaluations","Tool Usage":"False"}. This record does not assert independent reproduction.

### ShinkaEvolve

Binding Affinity (BA): 10.17. Result ID: 6a057a7c47f34ce924ec1fd1.

[Reporting paper](<https://www.sota2.com/research/paper/6a05571cdbc836b87d828d12.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa7b851e209131cea88df8.md>)

Recorded evaluation configuration: {"Guidance Strategy":"Affinity feedback","Seeded Runs":"3","Oracle budget":"1000 evaluations","Tool Usage":"False"}. This record does not assert independent reproduction.

### Graph-GA

Binding Affinity (BA): 10.21. Result ID: 6a057a7c47f34ce924ec1fd0.

[Reporting paper](<https://www.sota2.com/research/paper/6a05571cdbc836b87d828d12.md>)

Recorded evaluation configuration: {"Guidance Strategy":"Affinity feedback","Seeded Runs":"5","Oracle budget":"1000 evaluations","Tool Usage":"False"}. This record does not assert independent reproduction.

### PAFlow

Binding Affinity (BA): 10.63. Result ID: 6a057a7c47f34ce924ec1fcf.

[Reporting paper](<https://www.sota2.com/research/paper/6a05571cdbc836b87d828d12.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa7b111e209131cea867f8.md>)

Recorded evaluation configuration: {"Guidance Strategy":"Oracle-free","Seeded Runs":"3","Tool Usage":"False"}. This record does not assert independent reproduction.

### ToolMol

Binding Affinity (BA): 11. Result ID: 6a057a7c47f34ce924ec1fd4.

[Reporting paper](<https://www.sota2.com/research/paper/6a05571cdbc836b87d828d12.md>)

[Method origin paper](<https://www.sota2.com/research/paper/6a05571cdbc836b87d828d12.md>)

Recorded evaluation configuration: {"Guidance Strategy":"Affinity feedback","Seeded Runs":"5","Oracle budget":"1000 evaluations","Tool Usage":"True"}. This record does not assert independent reproduction.

### ShinkaEvolve

Binding Affinity (BA): 11.08. Result ID: 6a057a7c47f34ce924ec1fd2.

[Reporting paper](<https://www.sota2.com/research/paper/6a05571cdbc836b87d828d12.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa7b851e209131cea88df8.md>)

Recorded evaluation configuration: {"Guidance Strategy":"Affinity feedback","Seeded Runs":"3","Oracle budget":"1000 evaluations","Tool Usage":"True"}. This record does not assert independent reproduction.

### Pocket2Mol

Binding Affinity (BA): 11.27. Result ID: 6a057a7c47f34ce924ec1fcd.

[Reporting paper](<https://www.sota2.com/research/paper/6a05571cdbc836b87d828d12.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa5f7b1e209131ce9ea31b.md>)

Recorded evaluation configuration: {"Guidance Strategy":"Oracle-free","Seeded Runs":"3","Tool Usage":"False"}. This record does not assert independent reproduction.

### TAGMol

Binding Affinity (BA): 11.45. Result ID: 6a057a7c47f34ce924ec1fce.

[Reporting paper](<https://www.sota2.com/research/paper/6a05571cdbc836b87d828d12.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa5f601e209131ce9e9718.md>)

Recorded evaluation configuration: {"Guidance Strategy":"Oracle-free","Seeded Runs":"3","Tool Usage":"False"}. This record does not assert independent reproduction.

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