# Multi-cohort Biomarker Classification on CPTAC

Source: [Multi-cohort Biomarker Classification on CPTAC](<https://www.sota2.com/research/sota/multi-cohort-biomarker-classification-on-cptac>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2026-02-26T05:53:31.242Z

Evaluation of classification performance across multiple CPTAC cancer cohorts (including LUAD, BRCA, COAD, and NSCLC) based on specific molecular biomarkers.

A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage.

| Scope | Recorded value |
| --- | --- |
| Task | Classification |
| Dataset (including any stated split) | CPTAC |
| Metric | NSCLC ST Accuracy |
| Unit | PERCENT |
| Direction | Higher is better |
| Results loaded | 19 of 19 |
| Coverage | All results currently returned for this benchmark |

Evaluation settings may differ between results. The original papers and recorded configurations are needed to establish comparability. A shared metric name alone does not establish an identical protocol.

## Metrics

- [NSCLC ST Accuracy](<https://www.sota2.com/research/sota/multi-cohort-biomarker-classification-on-cptac.md?metric=NSCLC%20ST%20Accuracy>): Higher is better; unit: PERCENT.

- [LUAD STK11 Accuracy](<https://www.sota2.com/research/sota/multi-cohort-biomarker-classification-on-cptac.md?metric=LUAD%20STK11%20Accuracy>): Higher is better; unit: PERCENT.

- [LUAD EGFR Accuracy](<https://www.sota2.com/research/sota/multi-cohort-biomarker-classification-on-cptac.md?metric=LUAD%20EGFR%20Accuracy>): Higher is better; unit: PERCENT.

- [LUAD TP53 Accuracy](<https://www.sota2.com/research/sota/multi-cohort-biomarker-classification-on-cptac.md?metric=LUAD%20TP53%20Accuracy>): Higher is better; unit: PERCENT.

- [LUAD KRAS Accuracy](<https://www.sota2.com/research/sota/multi-cohort-biomarker-classification-on-cptac.md?metric=LUAD%20KRAS%20Accuracy>): Higher is better; unit: PERCENT.

- [BRCA ESR1 Accuracy](<https://www.sota2.com/research/sota/multi-cohort-biomarker-classification-on-cptac.md?metric=BRCA%20ESR1%20Accuracy>): Higher is better; unit: PERCENT.

- [BRCA PGR Accuracy](<https://www.sota2.com/research/sota/multi-cohort-biomarker-classification-on-cptac.md?metric=BRCA%20PGR%20Accuracy>): Higher is better; unit: PERCENT.

- [BRCA ERBB2 Accuracy](<https://www.sota2.com/research/sota/multi-cohort-biomarker-classification-on-cptac.md?metric=BRCA%20ERBB2%20Accuracy>): Higher is better; unit: PERCENT.

- [BRCA PIK3CA Accuracy](<https://www.sota2.com/research/sota/multi-cohort-biomarker-classification-on-cptac.md?metric=BRCA%20PIK3CA%20Accuracy>): Higher is better; unit: PERCENT.

- [MSI Accuracy](<https://www.sota2.com/research/sota/multi-cohort-biomarker-classification-on-cptac.md?metric=MSI%20Accuracy>): Higher is better; unit: PERCENT.

- [BRAF Accuracy](<https://www.sota2.com/research/sota/multi-cohort-biomarker-classification-on-cptac.md?metric=BRAF%20Accuracy>): Higher is better; unit: PERCENT.

- [COAD LN Accuracy](<https://www.sota2.com/research/sota/multi-cohort-biomarker-classification-on-cptac.md?metric=COAD%20LN%20Accuracy>): Higher is better; unit: PERCENT.

- [COAD KRAS Accuracy](<https://www.sota2.com/research/sota/multi-cohort-biomarker-classification-on-cptac.md?metric=COAD%20KRAS%20Accuracy>): Higher is better; unit: PERCENT.

- [COAD Side Accuracy](<https://www.sota2.com/research/sota/multi-cohort-biomarker-classification-on-cptac.md?metric=COAD%20Side%20Accuracy>): Higher is better; unit: PERCENT.

- [COAD PIK3CA Accuracy](<https://www.sota2.com/research/sota/multi-cohort-biomarker-classification-on-cptac.md?metric=COAD%20PIK3CA%20Accuracy>): Higher is better; unit: PERCENT.

- [Average Accuracy](<https://www.sota2.com/research/sota/multi-cohort-biomarker-classification-on-cptac.md?metric=Average%20Accuracy>): Higher is better; unit: PERCENT.

## Recorded results

| Method | NSCLC ST Accuracy | Result date | Report paper |
| --- | --- | --- | --- |
| COBRA-V2 | 99 | Not recorded | 68fa77981e209131cea743e8 |
| COBRA-V2 | 98.9 | Not recorded | 68fa77981e209131cea743e8 |
| Virchow2 | 98.3 | Not recorded | 68fa77981e209131cea743e8 |
| CONCH | 97.8 | Not recorded | 68fa77981e209131cea743e8 |
| COBRA-H0 | 97.6 | Not recorded | 68fa77981e209131cea743e8 |
| COBRA-UNI | 97.2 | Not recorded | 68fa77981e209131cea743e8 |
| COBRA-H0 | 97.1 | Not recorded | 68fa77981e209131cea743e8 |
| COBRA-UNI | 97.1 | Not recorded | 68fa77981e209131cea743e8 |
| COBRA-CTP | 96.6 | Not recorded | 68fa77981e209131cea743e8 |
| COBRA-CTP | 96.5 | Not recorded | 68fa77981e209131cea743e8 |
| GigaPath | 96.2 | Not recorded | 68fa77981e209131cea743e8 |
| CHIEF | 95.8 | Not recorded | 68fa77981e209131cea743e8 |
| MADELEINE | 95.4 | Not recorded | 68fa77981e209131cea743e8 |
| H-Optimus | 92.9 | Not recorded | 68fa77981e209131cea743e8 |
| UNI | 92.2 | Not recorded | 68fa77981e209131cea743e8 |
| PRISM | 91.6 | Not recorded | 68fa77981e209131cea743e8 |
| CTransPath | 91.5 | Not recorded | 68fa77981e209131cea743e8 |
| GigaPath-SE | 90.2 | Not recorded | 68fa77981e209131cea743e8 |
| Virchow | 81.7 | Not recorded | 68fa77981e209131cea743e8 |

### COBRA-V2

NSCLC ST Accuracy: 99. Result ID: 69954beb3badfaffe63b1d3d.

[Reporting paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

Recorded evaluation configuration: {"magnification":"5x","aggregation\_mode":"multi-FM weighting (Eq. 8)","backbone":"Virchow-2"}. This record does not assert independent reproduction.

### COBRA-V2

NSCLC ST Accuracy: 98.9. Result ID: 69954beb3badfaffe63b1d3c.

[Reporting paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

Recorded evaluation configuration: {"magnification":"5x","aggregation\_mode":"weighted aggregation (Eq. 6)","backbone":"Virchow-2"}. This record does not assert independent reproduction.

### Virchow2

NSCLC ST Accuracy: 98.3. Result ID: 69954beb3badfaffe63b1d31.

[Reporting paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa758d1e209131cea688d5.md>)

Recorded evaluation configuration: {"magnification":"5x"}. This record does not assert independent reproduction.

### CONCH

NSCLC ST Accuracy: 97.8. Result ID: 69954beb3badfaffe63b1d30.

[Reporting paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

Recorded evaluation configuration: {"magnification":"5x"}. This record does not assert independent reproduction.

### COBRA-H0

NSCLC ST Accuracy: 97.6. Result ID: 69954beb3badfaffe63b1d39.

[Reporting paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

Recorded evaluation configuration: {"magnification":"5x","aggregation\_mode":"weighted aggregation (Eq. 6)","backbone":"H-Optimus-0"}. This record does not assert independent reproduction.

### COBRA-UNI

NSCLC ST Accuracy: 97.2. Result ID: 69954beb3badfaffe63b1d35.

[Reporting paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

Recorded evaluation configuration: {"magnification":"5x","aggregation\_mode":"mean over patch embeddings","backbone":"UNI"}. This record does not assert independent reproduction.

### COBRA-H0

NSCLC ST Accuracy: 97.1. Result ID: 69954beb3badfaffe63b1d36.

[Reporting paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

Recorded evaluation configuration: {"magnification":"5x","aggregation\_mode":"mean over patch embeddings","backbone":"H-Optimus-0"}. This record does not assert independent reproduction.

### COBRA-UNI

NSCLC ST Accuracy: 97.1. Result ID: 69954beb3badfaffe63b1d3a.

[Reporting paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

Recorded evaluation configuration: {"magnification":"5x","aggregation\_mode":"weighted aggregation (Eq. 6)","backbone":"UNI"}. This record does not assert independent reproduction.

### COBRA-CTP

NSCLC ST Accuracy: 96.6. Result ID: 69954beb3badfaffe63b1d37.

[Reporting paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

Recorded evaluation configuration: {"magnification":"5x","aggregation\_mode":"mean over patch embeddings","backbone":"CTransPath"}. This record does not assert independent reproduction.

### COBRA-CTP

NSCLC ST Accuracy: 96.5. Result ID: 69954beb3badfaffe63b1d38.

[Reporting paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

Recorded evaluation configuration: {"magnification":"5x","aggregation\_mode":"weighted aggregation (Eq. 6)","backbone":"CTransPath"}. This record does not assert independent reproduction.

### GigaPath

NSCLC ST Accuracy: 96.2. Result ID: 69954bea3badfaffe63b1d2e.

[Reporting paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

Recorded evaluation configuration: {"magnification":"5x"}. This record does not assert independent reproduction.

### CHIEF

NSCLC ST Accuracy: 95.8. Result ID: 69954beb3badfaffe63b1d3b.

[Reporting paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

Recorded evaluation configuration: {"magnification":"5x"}. This record does not assert independent reproduction.

### MADELEINE

NSCLC ST Accuracy: 95.4. Result ID: 69954beb3badfaffe63b1d34.

[Reporting paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa745e1e209131cea613b1.md>)

Recorded evaluation configuration: {"magnification":"5x"}. This record does not assert independent reproduction.

### H-Optimus

NSCLC ST Accuracy: 92.9. Result ID: 69954bea3badfaffe63b1d2f.

[Reporting paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

Recorded evaluation configuration: {"magnification":"5x"}. This record does not assert independent reproduction.

### UNI

NSCLC ST Accuracy: 92.2. Result ID: 69954bea3badfaffe63b1d2d.

[Reporting paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

Recorded evaluation configuration: {"magnification":"5x"}. This record does not assert independent reproduction.

### PRISM

NSCLC ST Accuracy: 91.6. Result ID: 69954beb3badfaffe63b1d33.

[Reporting paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa73421e209131cea5b55b.md>)

Recorded evaluation configuration: {"magnification":"5x"}. This record does not assert independent reproduction.

### CTransPath

NSCLC ST Accuracy: 91.5. Result ID: 69954bea3badfaffe63b1d2c.

[Reporting paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

Recorded evaluation configuration: {"magnification":"5x"}. This record does not assert independent reproduction.

### GigaPath-SE

NSCLC ST Accuracy: 90.2. Result ID: 69954beb3badfaffe63b1d32.

[Reporting paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

Recorded evaluation configuration: {"magnification":"5x","slide\_encoder":true}. This record does not assert independent reproduction.

### Virchow

NSCLC ST Accuracy: 81.7. Result ID: 69954bea3badfaffe63b1d2b.

[Reporting paper](<https://www.sota2.com/research/paper/68fa77981e209131cea743e8.md>)

Recorded evaluation configuration: {"magnification":"5x"}. This record does not assert independent reproduction.

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