# Molecular Generation on c-MET top 15 molecules

Source: [Molecular Generation on c-MET top 15 molecules](<https://www.sota2.com/research/sota/molecular-generation-on-c-met-top-15-molecules>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2026-05-14T07:35:14.969Z

Evaluation of molecular generation models on the c-MET top 15 molecule dataset, assessed using metrics related to binding affinity (ABFE), drug-likeness (QED), and synthetic accessibility (SA).

A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage.

| Scope | Recorded value |
| --- | --- |
| Task | Molecular Generation |
| Dataset (including any stated split) | c-MET top 15 molecules |
| Metric | ABFE |
| Unit | SCALAR |
| Direction | Lower is better |
| Results loaded | 3 of 3 |
| Coverage | All results currently returned for this benchmark |

Evaluation settings may differ between results. The original papers and recorded configurations are needed to establish comparability. A shared metric name alone does not establish an identical protocol.

## Metrics

- [ABFE](<https://www.sota2.com/research/sota/molecular-generation-on-c-met-top-15-molecules.md?metric=ABFE>): Lower is better; unit: SCALAR.

- [QED](<https://www.sota2.com/research/sota/molecular-generation-on-c-met-top-15-molecules.md?metric=QED>): Higher is better; unit: PERCENT.

- [SA](<https://www.sota2.com/research/sota/molecular-generation-on-c-met-top-15-molecules.md?metric=SA>): Lower is better; unit: SCALAR.

## Recorded results

| Method | ABFE | Result date | Report paper |
| --- | --- | --- | --- |
| MF-LAL | 6.7 | Not recorded | 6a05571cdbc836b87d828d12 |
| ToolMol | 7.3 | Not recorded | 6a05571cdbc836b87d828d12 |
| ToolMol | 7.96 | Not recorded | 6a05571cdbc836b87d828d12 |

### MF-LAL

ABFE: 6.7. Result ID: 6a057a7c47f34ce924ec1fc7.

[Reporting paper](<https://www.sota2.com/research/paper/6a05571cdbc836b87d828d12.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa5f801e209131ce9ea6d0.md>)

Recorded evaluation configuration: {"Filtering Protocol":"None"}. This record does not assert independent reproduction.

### ToolMol

ABFE: 7.3. Result ID: 6a057a7c47f34ce924ec1fc9.

[Reporting paper](<https://www.sota2.com/research/paper/6a05571cdbc836b87d828d12.md>)

[Method origin paper](<https://www.sota2.com/research/paper/6a05571cdbc836b87d828d12.md>)

Recorded evaluation configuration: {"Filtering Protocol":"QED \> 0.5, SA \< 3.0 filter"}. This record does not assert independent reproduction.

### ToolMol

ABFE: 7.96. Result ID: 6a057a7c47f34ce924ec1fc8.

[Reporting paper](<https://www.sota2.com/research/paper/6a05571cdbc836b87d828d12.md>)

[Method origin paper](<https://www.sota2.com/research/paper/6a05571cdbc836b87d828d12.md>)

Recorded evaluation configuration: {"Filtering Protocol":"None (ranked solely on binding energy)"}. This record does not assert independent reproduction.

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