# Hit discovery (DMTA replay) on DUD-E Source: [Hit discovery (DMTA replay) on DUD-E]() Collection index: [llms.txt]() Data updated: 2026-04-09T23:38:02.753Z Evaluation of model performance on Hit Discovery using the DUD-E dataset, specifically focusing on the DMTA replay scenario. A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage. | Scope | Recorded value | | --- | --- | | Task | Hit discovery (DMTA replay) | | Dataset (including any stated split) | DUD-E | | Metric | Hit Rate | | Unit | PERCENT | | Direction | Higher is better | | Results loaded | 18 of 18 | | Coverage | All results currently returned for this benchmark | Evaluation settings may differ between results. The original papers and recorded configurations are needed to establish comparability. A shared metric name alone does not establish an identical protocol. ## Metrics - [Hit Rate](): Higher is better; unit: PERCENT. - [Enrichment Factor](): Higher is better; unit: SCALAR. - [Experiments to 50 Hits](): Lower is better; unit: SCALAR. ## Recorded results | Method | Hit Rate | Result date | Report paper | | --- | --- | --- | --- | | NESTDRUG | 87.6 | Not recorded | 69d7327c7d0172140ec76ac2 | | NESTDRUG | 82.7 | Not recorded | 69d7327c7d0172140ec76ac2 | | NESTDRUG | 78.9 | Not recorded | 69d7327c7d0172140ec76ac2 | | NESTDRUG | 76.1 | Not recorded | 69d7327c7d0172140ec76ac2 | | NESTDRUG | 73.4 | Not recorded | 69d7327c7d0172140ec76ac2 | | NESTDRUG | 71.8 | Not recorded | 69d7327c7d0172140ec76ac2 | | NESTDRUG | 69.2 | Not recorded | 69d7327c7d0172140ec76ac2 | | NESTDRUG | 62.4 | Not recorded | 69d7327c7d0172140ec76ac2 | | NESTDRUG | 58.1 | Not recorded | 69d7327c7d0172140ec76ac2 | | Random | 52.8 | Not recorded | 69d7327c7d0172140ec76ac2 | | Random | 51.2 | Not recorded | 69d7327c7d0172140ec76ac2 | | Random | 49.4 | Not recorded | 69d7327c7d0172140ec76ac2 | | Random | 47.6 | Not recorded | 69d7327c7d0172140ec76ac2 | | Random | 45.7 | Not recorded | 69d7327c7d0172140ec76ac2 | | Random | 44.8 | Not recorded | 69d7327c7d0172140ec76ac2 | | Random | 42.1 | Not recorded | 69d7327c7d0172140ec76ac2 | | Random | 39.4 | Not recorded | 69d7327c7d0172140ec76ac2 | | Random | 38.2 | Not recorded | 69d7327c7d0172140ec76ac2 | ### NESTDRUG Hit Rate: 87.6. Result ID: 69d836f547f34ce924bffc2c. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Target":"FXA","Rounds":"73"}. This record does not assert independent reproduction. ### NESTDRUG Hit Rate: 82.7. Result ID: 69d836f547f34ce924bffc26. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Target":"HDAC2","Rounds":"41"}. This record does not assert independent reproduction. ### NESTDRUG Hit Rate: 78.9. Result ID: 69d836f547f34ce924bffc28. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Target":"JAK2","Rounds":"38"}. This record does not assert independent reproduction. ### NESTDRUG Hit Rate: 76.1. Result ID: 69d836f547f34ce924bffc1e. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Target":"EGFR","Rounds":"141"}. This record does not assert independent reproduction. ### NESTDRUG Hit Rate: 73.4. Result ID: 69d836f547f34ce924bffc2e. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Target":"Mean","Rounds":"—"}. This record does not assert independent reproduction. ### NESTDRUG Hit Rate: 71.8. Result ID: 69d836f547f34ce924bffc20. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Target":"DRD2","Rounds":"89"}. This record does not assert independent reproduction. ### NESTDRUG Hit Rate: 69.2. Result ID: 69d836f547f34ce924bffc24. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Target":"ESR1","Rounds":"52"}. This record does not assert independent reproduction. ### NESTDRUG Hit Rate: 62.4. Result ID: 69d836f547f34ce924bffc22. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Target":"BACE1","Rounds":"67"}. This record does not assert independent reproduction. ### NESTDRUG Hit Rate: 58.1. Result ID: 69d836f547f34ce924bffc2a. [Reporting paper]() [Method origin paper]() Recorded evaluation configuration: {"Target":"PPARG","Rounds":"45"}. This record does not assert independent reproduction. ### Random Hit Rate: 52.8. Result ID: 69d836f547f34ce924bffc2b. [Reporting paper]() Recorded evaluation configuration: {"Target":"FXA","Rounds":"73"}. This record does not assert independent reproduction. ### Random Hit Rate: 51.2. Result ID: 69d836f547f34ce924bffc25. [Reporting paper]() Recorded evaluation configuration: {"Target":"HDAC2","Rounds":"41"}. This record does not assert independent reproduction. ### Random Hit Rate: 49.4. Result ID: 69d836f547f34ce924bffc1d. [Reporting paper]() Recorded evaluation configuration: {"Target":"EGFR","Rounds":"141"}. This record does not assert independent reproduction. ### Random Hit Rate: 47.6. Result ID: 69d836f547f34ce924bffc27. [Reporting paper]() Recorded evaluation configuration: {"Target":"JAK2","Rounds":"38"}. This record does not assert independent reproduction. ### Random Hit Rate: 45.7. Result ID: 69d836f547f34ce924bffc2d. [Reporting paper]() Recorded evaluation configuration: {"Target":"Mean","Rounds":"—"}. This record does not assert independent reproduction. ### Random Hit Rate: 44.8. Result ID: 69d836f547f34ce924bffc23. [Reporting paper]() Recorded evaluation configuration: {"Target":"ESR1","Rounds":"52"}. This record does not assert independent reproduction. ### Random Hit Rate: 42.1. Result ID: 69d836f547f34ce924bffc1f. [Reporting paper]() Recorded evaluation configuration: {"Target":"DRD2","Rounds":"89"}. This record does not assert independent reproduction. ### Random Hit Rate: 39.4. Result ID: 69d836f547f34ce924bffc29. [Reporting paper]() Recorded evaluation configuration: {"Target":"PPARG","Rounds":"45"}. This record does not assert independent reproduction. ### Random Hit Rate: 38.2. Result ID: 69d836f547f34ce924bffc21. [Reporting paper]() Recorded evaluation configuration: {"Target":"BACE1","Rounds":"67"}. This record does not assert independent reproduction. Page 1 of 1. This is an index page, not the full collection.