# Gene Regulatory Network Inference on SIM350 5% noise (test)

Source: [Gene Regulatory Network Inference on SIM350 5% noise (test)](<https://www.sota2.com/research/sota/gene-regulatory-network-inference-on-sim350-5-percent-noise-test>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2026-02-26T06:04:31.614Z

Evaluation of models for inferring gene regulatory networks using the SIM350 dataset variant containing 5% noise, assessed using metrics like Sparsity and Balanced Accuracy.

A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage.

| Scope | Recorded value |
| --- | --- |
| Task | Gene regulatory network inference |
| Dataset (including any stated split) | SIM350 5% noise (test) |
| Metric | Sparsity |
| Unit | PERCENT |
| Direction | Higher is better |
| Results loaded | 12 of 12 |
| Coverage | All results currently returned for this benchmark |

Evaluation settings may differ between results. The original papers and recorded configurations are needed to establish comparability. A shared metric name alone does not establish an identical protocol.

## Metrics

- [Sparsity](<https://www.sota2.com/research/sota/gene-regulatory-network-inference-on-sim350-5-percent-noise-test.md?metric=Sparsity>): Higher is better; unit: PERCENT.

- [Balanced Accuracy](<https://www.sota2.com/research/sota/gene-regulatory-network-inference-on-sim350-5-percent-noise-test.md?metric=Balanced%20Accuracy>): Higher is better; unit: PERCENT.

## Recorded results

| Method | Sparsity | Result date | Report paper |
| --- | --- | --- | --- |
| SparseFlow | 96 | Not recorded | 68fa5f6e1e209131ce9e9cf7 |
| DASH | 94.6 | Not recorded | 68fa5f6e1e209131ce9e9cf7 |
| DST | 92.8 | Not recorded | 68fa5f6e1e209131ce9e9cf7 |
| PINN + MP | 87 | Not recorded | 68fa5f6e1e209131ce9e9cf7 |
| BioPrune | 83.5 | Not recorded | 68fa5f6e1e209131ce9e9cf7 |
| IMP | 81.9 | Not recorded | 68fa5f6e1e209131ce9e9cf7 |
| Iter. SynFlow | 79.3 | Not recorded | 68fa5f6e1e209131ce9e9cf7 |
| PathReg | 56.5 | Not recorded | 68fa5f6e1e209131ce9e9cf7 |
| L0 | 33.8 | Not recorded | 68fa5f6e1e209131ce9e9cf7 |
| PINN | 9.9 | Not recorded | 68fa5f6e1e209131ce9e9cf7 |
| None/Baseline | 7.5 | Not recorded | 68fa5f6e1e209131ce9e9cf7 |
| C-NODE | 6.2 | Not recorded | 68fa5f6e1e209131ce9e9cf7 |

### SparseFlow

Sparsity: 96. Result ID: 698bc6fd7a967eddb7714681.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa6b421e209131cea2d093.md>)

Recorded evaluation configuration: {"Strategy category":"Pruning-based (explicit)","Prior-informed":false}. This record does not assert independent reproduction.

### DASH

Sparsity: 94.6. Result ID: 698bc6fd7a967eddb7714683.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Implementation](<https://github.com/QuackenbushLab/DASH>)

Recorded evaluation configuration: {"Strategy category":"Pruning-based (explicit)","Prior-informed":true}. This record does not assert independent reproduction.

### DST

Sparsity: 92.8. Result ID: 698bc6fd7a967eddb771467e.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa67881e209131cea16aff.md>)

Recorded evaluation configuration: {"Strategy category":"Penalty-based (implicit)","Prior-informed":false}. This record does not assert independent reproduction.

### PINN + MP

Sparsity: 87. Result ID: 698bc6fd7a967eddb7714684.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Implementation](<https://github.com/QuackenbushLab/DASH>)

Recorded evaluation configuration: {"Strategy category":"Hybrid","Prior-informed":true}. This record does not assert independent reproduction.

### BioPrune

Sparsity: 83.5. Result ID: 698bc6fd7a967eddb7714682.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Implementation](<https://github.com/QuackenbushLab/DASH>)

Recorded evaluation configuration: {"Strategy category":"Pruning-based (explicit)","Prior-informed":true}. This record does not assert independent reproduction.

### IMP

Sparsity: 81.9. Result ID: 698bc6fd7a967eddb771467f.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa656f1e209131cea0a651.md>)

Recorded evaluation configuration: {"Strategy category":"Pruning-based (explicit)","Prior-informed":false}. This record does not assert independent reproduction.

### Iter. SynFlow

Sparsity: 79.3. Result ID: 698bc6fd7a967eddb7714680.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa3d821e209131ce8e0b67.md>)

Recorded evaluation configuration: {"Strategy category":"Pruning-based (explicit)","Prior-informed":false}. This record does not assert independent reproduction.

### PathReg

Sparsity: 56.5. Result ID: 698bc6fd7a967eddb771467c.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa6dc21e209131cea3be2b.md>)

[Implementation](<https://github.com/theislab/PathReg>)

Recorded evaluation configuration: {"Strategy category":"Penalty-based (implicit)","Prior-informed":false}. This record does not assert independent reproduction.

### L0

Sparsity: 33.8. Result ID: 698bc6fd7a967eddb771467a.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa647d1e209131cea04d19.md>)

Recorded evaluation configuration: {"Strategy category":"Penalty-based (implicit)","Prior-informed":false}. This record does not assert independent reproduction.

### PINN

Sparsity: 9.9. Result ID: 698bc6fd7a967eddb771467d.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

Recorded evaluation configuration: {"Strategy category":"Penalty-based (implicit)","Prior-informed":true}. This record does not assert independent reproduction.

### None/Baseline

Sparsity: 7.5. Result ID: 698bc6fd7a967eddb7714679.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

Recorded evaluation configuration: {"Strategy category":"None","Prior-informed":false}. This record does not assert independent reproduction.

### C-NODE

Sparsity: 6.2. Result ID: 698bc6fd7a967eddb771467b.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa76cc1e209131cea6f218.md>)

Recorded evaluation configuration: {"Strategy category":"Penalty-based (implicit)","Prior-informed":false}. This record does not assert independent reproduction.

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