# Gene regulatory dynamics prediction on SIM350 5% noise (test)

Source: [Gene regulatory dynamics prediction on SIM350 5% noise (test)](<https://www.sota2.com/research/sota/gene-regulatory-dynamics-prediction-on-sim350-5-percent-noise-test>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2026-02-26T05:50:35.497Z

Evaluation of models predicting gene regulatory dynamics using the SIM350 dataset, specifically the 5% noise test split.

A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage.

| Scope | Recorded value |
| --- | --- |
| Task | Gene regulatory dynamics prediction |
| Dataset (including any stated split) | SIM350 5% noise (test) |
| Metric | MSE |
| Unit | SCALAR |
| Direction | Lower is better |
| Results loaded | 12 of 12 |
| Coverage | All results currently returned for this benchmark |

Evaluation settings may differ between results. The original papers and recorded configurations are needed to establish comparability. A shared metric name alone does not establish an identical protocol.

## Metrics

- [MSE](<https://www.sota2.com/research/sota/gene-regulatory-dynamics-prediction-on-sim350-5-percent-noise-test.md?metric=MSE>): Lower is better; unit: SCALAR.

## Recorded results

| Method | MSE | Result date | Report paper |
| --- | --- | --- | --- |
| PINN + MP | 2.3 | Not recorded | 68fa5f6e1e209131ce9e9cf7 |
| DASH | 2.4 | Not recorded | 68fa5f6e1e209131ce9e9cf7 |
| PINN | 2.5 | Not recorded | 68fa5f6e1e209131ce9e9cf7 |
| BioPrune | 2.6 | Not recorded | 68fa5f6e1e209131ce9e9cf7 |
| C-NODE | 2.8 | Not recorded | 68fa5f6e1e209131ce9e9cf7 |
| None/Baseline | 3 | Not recorded | 68fa5f6e1e209131ce9e9cf7 |
| SparseFlow | 3.6 | Not recorded | 68fa5f6e1e209131ce9e9cf7 |
| DST | 4 | Not recorded | 68fa5f6e1e209131ce9e9cf7 |
| IMP | 4.7 | Not recorded | 68fa5f6e1e209131ce9e9cf7 |
| Iter. SynFlow | 7 | Not recorded | 68fa5f6e1e209131ce9e9cf7 |
| PathReg | 8 | Not recorded | 68fa5f6e1e209131ce9e9cf7 |
| L0 | 8.5 | Not recorded | 68fa5f6e1e209131ce9e9cf7 |

### PINN + MP

MSE: 2.3. Result ID: 698bc6fd7a967eddb7714690.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Implementation](<https://github.com/QuackenbushLab/DASH>)

Recorded evaluation configuration: {"Strategy category":"Hybrid","Prior-informed":true}. This record does not assert independent reproduction.

### DASH

MSE: 2.4. Result ID: 698bc6fd7a967eddb771468f.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Implementation](<https://github.com/QuackenbushLab/DASH>)

Recorded evaluation configuration: {"Strategy category":"Pruning-based (explicit)","Prior-informed":true}. This record does not assert independent reproduction.

### PINN

MSE: 2.5. Result ID: 698bc6fd7a967eddb7714689.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

Recorded evaluation configuration: {"Strategy category":"Penalty-based (implicit)","Prior-informed":true}. This record does not assert independent reproduction.

### BioPrune

MSE: 2.6. Result ID: 698bc6fd7a967eddb771468e.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Implementation](<https://github.com/QuackenbushLab/DASH>)

Recorded evaluation configuration: {"Strategy category":"Pruning-based (explicit)","Prior-informed":true}. This record does not assert independent reproduction.

### C-NODE

MSE: 2.8. Result ID: 698bc6fd7a967eddb7714687.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa76cc1e209131cea6f218.md>)

Recorded evaluation configuration: {"Strategy category":"Penalty-based (implicit)","Prior-informed":false}. This record does not assert independent reproduction.

### None/Baseline

MSE: 3. Result ID: 698bc6fd7a967eddb7714685.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

Recorded evaluation configuration: {"Strategy category":"None","Prior-informed":false}. This record does not assert independent reproduction.

### SparseFlow

MSE: 3.6. Result ID: 698bc6fd7a967eddb771468d.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa6b421e209131cea2d093.md>)

Recorded evaluation configuration: {"Strategy category":"Pruning-based (explicit)","Prior-informed":false}. This record does not assert independent reproduction.

### DST

MSE: 4. Result ID: 698bc6fd7a967eddb771468a.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa67881e209131cea16aff.md>)

Recorded evaluation configuration: {"Strategy category":"Penalty-based (implicit)","Prior-informed":false}. This record does not assert independent reproduction.

### IMP

MSE: 4.7. Result ID: 698bc6fd7a967eddb771468b.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa656f1e209131cea0a651.md>)

Recorded evaluation configuration: {"Strategy category":"Pruning-based (explicit)","Prior-informed":false}. This record does not assert independent reproduction.

### Iter. SynFlow

MSE: 7. Result ID: 698bc6fd7a967eddb771468c.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa3d821e209131ce8e0b67.md>)

Recorded evaluation configuration: {"Strategy category":"Pruning-based (explicit)","Prior-informed":false}. This record does not assert independent reproduction.

### PathReg

MSE: 8. Result ID: 698bc6fd7a967eddb7714688.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa6dc21e209131cea3be2b.md>)

[Implementation](<https://github.com/theislab/PathReg>)

Recorded evaluation configuration: {"Strategy category":"Penalty-based (implicit)","Prior-informed":false}. This record does not assert independent reproduction.

### L0

MSE: 8.5. Result ID: 698bc6fd7a967eddb7714686.

[Reporting paper](<https://www.sota2.com/research/paper/68fa5f6e1e209131ce9e9cf7.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa647d1e209131cea04d19.md>)

Recorded evaluation configuration: {"Strategy category":"Penalty-based (implicit)","Prior-informed":false}. This record does not assert independent reproduction.

Page 1 of 1. This is an index page, not the full collection.
