# Description-guided Molecular Generation on Description-guided Generation

Source: [Description-guided Molecular Generation on Description-guided Generation](<https://www.sota2.com/research/sota/description-guided-molecular-generation-on-description-guided-generation>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2026-02-26T05:41:37.305Z

Evaluation of generative models tasked with creating molecules based on specific textual descriptions, assessed using Exact Match (EM), Fingerprint Similarity (FTS), and molecular Validity rates.

A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage.

| Scope | Recorded value |
| --- | --- |
| Task | Description-guided Molecular Generation |
| Dataset (including any stated split) | Description-guided Generation |
| Metric | EM |
| Unit | PERCENT |
| Direction | Higher is better |
| Results loaded | 8 of 8 |
| Coverage | All results currently returned for this benchmark |

Evaluation settings may differ between results. The original papers and recorded configurations are needed to establish comparability. A shared metric name alone does not establish an identical protocol.

## Metrics

- [EM](<https://www.sota2.com/research/sota/description-guided-molecular-generation-on-description-guided-generation.md?metric=EM>): Higher is better; unit: PERCENT.

- [FTS](<https://www.sota2.com/research/sota/description-guided-molecular-generation-on-description-guided-generation.md?metric=FTS>): Higher is better; unit: PERCENT.

- [Validity Rate](<https://www.sota2.com/research/sota/description-guided-molecular-generation-on-description-guided-generation.md?metric=Validity%20Rate>): Higher is better; unit: PERCENT.

## Recorded results

| Method | EM | Result date | Report paper |
| --- | --- | --- | --- |
| Mol-T5 | 31.7 | Not recorded | 693266f5d6b0dd33429341ce |
| BioMedGPT-Mol | 29.6 | Not recorded | 693266f5d6b0dd33429341ce |
| LlaSMol | 19.2 | Not recorded | 693266f5d6b0dd33429341ce |
| Claude3 Opus | 12.3 | Not recorded | 693266f5d6b0dd33429341ce |
| GPT-4 | 6.4 | Not recorded | 693266f5d6b0dd33429341ce |
| Molinst | 6 | Not recorded | 693266f5d6b0dd33429341ce |
| ChemLLM | 0.9 | Not recorded | 693266f5d6b0dd33429341ce |
| Galactica | 0 | Not recorded | 693266f5d6b0dd33429341ce |

### Mol-T5

EM: 31.7. Result ID: 69962f245698665ec470d5ee.

[Reporting paper](<https://www.sota2.com/research/paper/693266f5d6b0dd33429341ce.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa6dde1e209131cea3c90f.md>)

[Implementation](<https://github.com/blender-nlp/MolT5>)

Recorded evaluation configuration: {"Model Category":"Task Specific, Non-LLM based Models"}. This record does not assert independent reproduction.

### BioMedGPT-Mol

EM: 29.6. Result ID: 69962f245698665ec470d5f5.

[Reporting paper](<https://www.sota2.com/research/paper/693266f5d6b0dd33429341ce.md>)

[Method origin paper](<https://www.sota2.com/research/paper/693266f5d6b0dd33429341ce.md>)

Recorded evaluation configuration: {"Model Category":"Chemistry LLM"}. This record does not assert independent reproduction.

### LlaSMol

EM: 19.2. Result ID: 69962f245698665ec470d5f4.

[Reporting paper](<https://www.sota2.com/research/paper/693266f5d6b0dd33429341ce.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa74701e209131cea61c9f.md>)

Recorded evaluation configuration: {"Model Category":"Chemistry LLM"}. This record does not assert independent reproduction.

### Claude3 Opus

EM: 12.3. Result ID: 69962f245698665ec470d5f1.

[Reporting paper](<https://www.sota2.com/research/paper/693266f5d6b0dd33429341ce.md>)

Recorded evaluation configuration: {"Model Category":"General LLM"}. This record does not assert independent reproduction.

### GPT-4

EM: 6.4. Result ID: 69962f245698665ec470d5f0.

[Reporting paper](<https://www.sota2.com/research/paper/693266f5d6b0dd33429341ce.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa727a1e209131cea56a1e.md>)

[Implementation](<https://github.com/openai/evals>)

Recorded evaluation configuration: {"Model Category":"General LLM"}. This record does not assert independent reproduction.

### Molinst

EM: 6. Result ID: 69962f245698665ec470d5f3.

[Reporting paper](<https://www.sota2.com/research/paper/693266f5d6b0dd33429341ce.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa5f5d1e209131ce9e955c.md>)

Recorded evaluation configuration: {"Model Category":"Chemistry LLM"}. This record does not assert independent reproduction.

### ChemLLM

EM: 0.9. Result ID: 69962f245698665ec470d5f2.

[Reporting paper](<https://www.sota2.com/research/paper/693266f5d6b0dd33429341ce.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa730e1e209131cea5a283.md>)

Recorded evaluation configuration: {"Model Category":"Chemistry LLM"}. This record does not assert independent reproduction.

### Galactica

EM: 0. Result ID: 69962f245698665ec470d5ef.

[Reporting paper](<https://www.sota2.com/research/paper/693266f5d6b0dd33429341ce.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa6dff1e209131cea3d479.md>)

[Implementation](<https://www.sota2.com/galactica.org>)

Recorded evaluation configuration: {"Model Category":"General LLM"}. This record does not assert independent reproduction.

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