# Anatomy and Pathology Image Synthesis on ADNI3 (test)

Source: [Anatomy and Pathology Image Synthesis on ADNI3 (test)](<https://www.sota2.com/research/sota/anatomy-and-pathology-image-synthesis-on-adni3-test>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2026-02-26T05:47:59.270Z

Evaluation of models performing Anatomy and Pathology Image Synthesis on the test split of the ADNI3 dataset, assessed using image quality metrics like L1, PSNR, and SSIM.

A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage.

| Scope | Recorded value |
| --- | --- |
| Task | Anatomy and Pathology Image Synthesis |
| Dataset (including any stated split) | ADNI3 (test) |
| Metric | L1 Loss |
| Unit | SCALAR |
| Direction | Lower is better |
| Results loaded | 10 of 10 |
| Coverage | All results currently returned for this benchmark |

Evaluation settings may differ between results. The original papers and recorded configurations are needed to establish comparability. A shared metric name alone does not establish an identical protocol.

## Metrics

- [L1 Loss](<https://www.sota2.com/research/sota/anatomy-and-pathology-image-synthesis-on-adni3-test.md?metric=L1%20Loss>): Lower is better; unit: SCALAR.

- [PSNR](<https://www.sota2.com/research/sota/anatomy-and-pathology-image-synthesis-on-adni3-test.md?metric=PSNR>): Higher is better; unit: SCALAR.

- [SSIM](<https://www.sota2.com/research/sota/anatomy-and-pathology-image-synthesis-on-adni3-test.md?metric=SSIM>): Higher is better; unit: SCALAR.

## Recorded results

| Method | L1 Loss | Result date | Report paper |
| --- | --- | --- | --- |
| PEPSI (Proposed) | 0.023 | Not recorded | 68fa72741e209131cea56710 |
| Brain-ID | 0.026 | Not recorded | 68fa72741e209131cea56710 |
| SynthSR | 0.027 | Not recorded | 68fa72741e209131cea56710 |
| PEPSI (SG-Anat) | 0.027 | Not recorded | 68fa72741e209131cea56710 |
| PEPSI (No-Seg) | 0.027 | Not recorded | 68fa72741e209131cea56710 |
| PEPSI (Dir-Seg) | 0.029 | Not recorded | 68fa72741e209131cea56710 |
| PEPSI (Proposed) | 0.034 | Not recorded | 68fa72741e209131cea56710 |
| PEPSI (No-Seg) | 0.0396 | Not recorded | 68fa72741e209131cea56710 |
| PEPSI (Dir-Seg) | 0.041 | Not recorded | 68fa72741e209131cea56710 |
| PEPSI (SG-Pathol) | 0.044 | Not recorded | 68fa72741e209131cea56710 |

### PEPSI (Proposed)

L1 Loss: 0.023. Result ID: 69923a0f3a6c3148490d74e8.

[Reporting paper](<https://www.sota2.com/research/paper/68fa72741e209131cea56710.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa72741e209131cea56710.md>)

[Implementation](<https://github.com/peirong26/PEPSI>)

Recorded evaluation configuration: {"Backbone":"3D UNet"}. This record does not assert independent reproduction.

### Brain-ID

L1 Loss: 0.026. Result ID: 69923a0f3a6c3148490d74e4.

[Reporting paper](<https://www.sota2.com/research/paper/68fa72741e209131cea56710.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa72721e209131cea565d0.md>)

Recorded evaluation configuration: {"Backbone":"3D UNet"}. This record does not assert independent reproduction.

### SynthSR

L1 Loss: 0.027. Result ID: 69923a0f3a6c3148490d74e3.

[Reporting paper](<https://www.sota2.com/research/paper/68fa72741e209131cea56710.md>)

Recorded evaluation configuration: {"Backbone":"3D UNet"}. This record does not assert independent reproduction.

### PEPSI (SG-Anat)

L1 Loss: 0.027. Result ID: 69923a0f3a6c3148490d74e5.

[Reporting paper](<https://www.sota2.com/research/paper/68fa72741e209131cea56710.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa72741e209131cea56710.md>)

[Implementation](<https://github.com/peirong26/PEPSI>)

Recorded evaluation configuration: {"Backbone":"3D UNet","Guidance":"Single-guidance from MR-RAGE"}. This record does not assert independent reproduction.

### PEPSI (No-Seg)

L1 Loss: 0.027. Result ID: 69923a0f3a6c3148490d74e6.

[Reporting paper](<https://www.sota2.com/research/paper/68fa72741e209131cea56710.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa72741e209131cea56710.md>)

[Implementation](<https://github.com/peirong26/PEPSI>)

Recorded evaluation configuration: {"Backbone":"3D UNet","Supervision":"No direct supervision from gold-standard pathology segmentations"}. This record does not assert independent reproduction.

### PEPSI (Dir-Seg)

L1 Loss: 0.029. Result ID: 69923a0f3a6c3148490d74e7.

[Reporting paper](<https://www.sota2.com/research/paper/68fa72741e209131cea56710.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa72741e209131cea56710.md>)

[Implementation](<https://github.com/peirong26/PEPSI>)

Recorded evaluation configuration: {"Backbone":"3D UNet","Supervision":"Direct supervision from gold-standard pathology segmentations"}. This record does not assert independent reproduction.

### PEPSI (Proposed)

L1 Loss: 0.034. Result ID: 69923a0f3a6c3148490d74ec.

[Reporting paper](<https://www.sota2.com/research/paper/68fa72741e209131cea56710.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa72741e209131cea56710.md>)

[Implementation](<https://github.com/peirong26/PEPSI>)

Recorded evaluation configuration: {"Backbone":"3D UNet"}. This record does not assert independent reproduction.

### PEPSI (No-Seg)

L1 Loss: 0.0396. Result ID: 69923a0f3a6c3148490d74ea.

[Reporting paper](<https://www.sota2.com/research/paper/68fa72741e209131cea56710.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa72741e209131cea56710.md>)

[Implementation](<https://github.com/peirong26/PEPSI>)

Recorded evaluation configuration: {"Backbone":"3D UNet","Supervision":"No direct supervision from gold-standard pathology segmentations"}. This record does not assert independent reproduction.

### PEPSI (Dir-Seg)

L1 Loss: 0.041. Result ID: 69923a0f3a6c3148490d74eb.

[Reporting paper](<https://www.sota2.com/research/paper/68fa72741e209131cea56710.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa72741e209131cea56710.md>)

[Implementation](<https://github.com/peirong26/PEPSI>)

Recorded evaluation configuration: {"Backbone":"3D UNet","Supervision":"Direct supervision from gold-standard pathology segmentations"}. This record does not assert independent reproduction.

### PEPSI (SG-Pathol)

L1 Loss: 0.044. Result ID: 69923a0f3a6c3148490d74e9.

[Reporting paper](<https://www.sota2.com/research/paper/68fa72741e209131cea56710.md>)

[Method origin paper](<https://www.sota2.com/research/paper/68fa72741e209131cea56710.md>)

[Implementation](<https://github.com/peirong26/PEPSI>)

Recorded evaluation configuration: {"Backbone":"3D UNet","Guidance":"Single-guidance from FLAIR"}. This record does not assert independent reproduction.

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