# Kinetic Superselectivity in Multivalent Binding

Source: [Kinetic Superselectivity in Multivalent Binding](<https://www.sota2.com/research/paper/6a167acadbd7150506f801db>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2026-05-28T05:00:13.160Z

Authors: Vid Ravnik, Baptiste Chabaud, Urban Bren, Galina V. Dubacheva, Tine Curk

Published: 2026-05-26T13:36:39.000Z

## Abstract

Multivalent binding employs multiple simultaneous supramolecular interactions, increasing avidity and selectivity compared with monovalent binding. While equilibrium aspects of multivalency are well characterized, non-equilibrium behavior remains poorly understood. By combining experiments on hyaluronic acid polymers with kinetic modeling based on stochastic chemical kinetics and molecular dynamics simulations, we systematically investigate the kinetics of multivalent binding. Notably, we find that both association and dissociation kinetics can be more selective than equilibrium binding. We explain this behavior using a two-step binding model featuring a combination of fast, weak and slow, strong interactions. These findings demonstrate a new approach: superselective targeting based on the association rate instead of the equilibrium state. The kinetic theory and experiments presented here provide a fundamental understanding of multivalent kinetics and establish design rules for superselective targeting in out-of-equilibrium systems.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/2605.27019>)

[PDF](<https://arxiv.org/pdf/2605.27019.pdf>)