# Memory-driven topological ordering during the transition from dormant to migrating epithelia

Source: [Memory-driven topological ordering during the transition from dormant to migrating epithelia](<https://www.sota2.com/research/paper/6a13d75c6f71c5ae7dc9e6fe>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2026-05-26T05:00:05.667Z

Authors: Richard Ho, Anna L{\\aa}ng, Emma L{\\aa}ng, Stig Ove B{\\o}e, Luiza Angheluta

Published: 2026-05-22T07:52:32.000Z

## Abstract

Transitions from quiescence to collective migration in epithelia underlie wound healing and cancer invasion, yet their physical origin remains poorly understood. Here we show that quiescent epithelial monolayers store spatially contractile stresses that function as a form of mechanical memory. Upon serum-induced reactivation, these pre-stressed regions nucleate extensile asters that emit propagating polarity domain walls. Along these interfaces, topological defects are created, advected and annihilated, leading to defect coarsening with faster kinetics than by elastic interactions. An active elastic model quantitatively reproduces the observed dynamics and identifies stored stress as the origin of rapid topological reorganization. Our results establish a mechanism in which mechanical memory in quiescent epithelia triggers active stress release, driving collective migration via rapid topological ordering, distinct from conventional unjamming and flocking transitions.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/2605.23339>)

[PDF](<https://arxiv.org/pdf/2605.23339.pdf>)