# Vision-Core Guided Contrastive Learning for Balanced Multi-modal Prognosis Prediction of Stroke Source: [Vision-Core Guided Contrastive Learning for Balanced Multi-modal Prognosis Prediction of Stroke]() Collection index: [llms.txt]() Data updated: 2026-05-16T05:00:12.406Z Authors: Liren Chen, Lidong Sun, Mingyan Huang, Junzhe Tang, Yinghui Zhu, Guanjie Wang, Yiqing Xia, Ting Xiao Published: 2026-05-14T11:28:57.000Z ## Abstract Deep learning and multi-modal fusion have demonstrated transformative potential in medical diagnosis by integrating diverse data sources. However, accurate prognosis for ischemic stroke remains challenging due to limitations in existing multi-modal approaches. First, current methods are predominantly confined to dual-modal fusion, lacking a framework that effectively integrates the trifecta of medical images, structured clinical data, and unstructured text. Second, they often fail to establish deep bidirectional interactions between modalities; To address these critical gaps, this paper proposes a novel tri-modal fusion model for ischemic stroke prognosis. Our approach first enriches the data representation by employing a Large Language Model (LLM) to automatically generate semi-structured diagnostic text from brain MRIs. This process not only addresses the scarcity of expert annotations but also serves as a regularized semantic enhancement, improving multimodal fusion robustness. Furthermore, we design a core component termed the Vision-Conditioned Dual Alignment Fusion Module (VDAFM), which strategically uses visual features as a conditional prior to guide fine-grained interaction with the generated text. This module achieves a dynamic and profound fusion through a dual semantic alignment loss, effectively mitigating modal heterogeneity. Extensive experiments on a real-world clinical dataset demonstrate that our model achieves state-of-the-art performance. ## Recorded benchmark results A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage. - [Prognosis prediction on Multi-center clinical dataset](): Prognosis Prediction; Multi-center clinical dataset; AUC: 81.06. ## Original sources and implementation [Original paper]() [PDF]()