# Competition of carrier bioresorption and drug release kinetics of vancomycin-loaded silicate macroporous microspheres to determine cell biocompatibility

Source: [Competition of carrier bioresorption and drug release kinetics of vancomycin-loaded silicate macroporous microspheres to determine cell biocompatibility](<https://www.sota2.com/research/paper/69e7048b7d0172140ec7ec9f>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2026-04-22T05:21:28.943Z

Authors: A. Bolandparvaz Jahromi, E. Salahinejad

Published: 2026-04-07T22:22:26.000Z

## Abstract

Bioceramic porous microspheres are promising substances for dental and orthopedic bone void filling, tissue engineering and drug delivery applications. In this research, the structure and cytocompatibility of bioactive magnesium-calcium silicate macroporous microspheres loaded with vancomycin hydrochloride, an antibiotic drug, were studied. In this regard, bredigite (Ca7MgSi4O16), akermanite (Ca2MgSi2O7) and diopside (CaMgSi2O6) carriers were fabricated through a sequence of sol-gel, calcination, droplet extrusion and sintering processes, followed by impregnated with vancomycin. X-ray diffraction (XRD) and scanning electron microscopy verified the formation of the desired ceramic crystalline phases and macroporous characteristics of the carriers, respectively. Based on the MTT assay, the antibiotic-loaded bredigite, akermanite and diopside devices comparatively exhibited the lowest, intermediate and highest levels of human bone marrow mesenchymal stem cells (hBM-MSCs) viability and proliferation, respectively. It was concluded that the role of the carrier bioresorption kinetics prevails over the drug delivery kinetics in determining the cell biocompatibility of the devices.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/2604.16454>)

[PDF](<https://arxiv.org/pdf/2604.16454.pdf>)