# MedBioLM: Optimizing Medical and Biological QA with Fine-Tuned Large Language Models and Retrieval-Augmented Generation Source: [MedBioLM: Optimizing Medical and Biological QA with Fine-Tuned Large Language Models and Retrieval-Augmented Generation]() Collection index: [llms.txt]() Data updated: 2025-10-26T04:03:16.343Z Authors: Seonok Kim Published: 2025-02-05T08:58:35.000Z ## Abstract Large Language Models (LLMs) have demonstrated impressive capabilities across natural language processing tasks. However, their application to specialized domains such as medicine and biology requires further optimization to ensure factual accuracy, reliability, and contextual depth. We introduce MedBioLM, a domain-adapted biomedical question-answering model designed to enhance both short-form and long-form queries. By integrating fine-tuning and retrieval-augmented generation (RAG), MedBioLM dynamically incorporates domain-specific knowledge, improving reasoning abilities and factual accuracy. To evaluate its effectiveness, we fine-tuned the model on diverse biomedical QA datasets, covering structured multiple-choice assessments and complex clinical reasoning tasks. Fine-tuning significantly improves accuracy on benchmark datasets, while RAG enhances factual consistency. These results highlight the potential of domain-optimized LLMs in advancing biomedical research, medical education, and clinical decision support. ## Recorded benchmark results A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage. - [Medical Question Answering on MedicationQA full n=674 (test)](): Medical Question Answering; MedicationQA full n=674 (test); F1 Score: 22. ## Original sources and implementation [Original paper]() [PDF]()