# Foundation Models for Slide-level Cancer Subtyping in Digital Pathology Source: [Foundation Models for Slide-level Cancer Subtyping in Digital Pathology]() Collection index: [llms.txt]() Data updated: 2025-10-26T03:32:00.805Z Authors: Pablo Meseguer, Roc\\'io del Amor, Adrian Colomer, Valery Naranjo Published: 2024-10-21T11:04:58.000Z ## Abstract Since the emergence of the ImageNet dataset, the pretraining and fine-tuning approach has become widely adopted in computer vision due to the ability of ImageNet-pretrained models to learn a wide variety of visual features. However, a significant challenge arises when adapting these models to domain-specific fields, such as digital pathology, due to substantial gaps between domains. To address this limitation, foundation models (FM) have been trained on large-scale in-domain datasets to learn the intricate features of histopathology images. In cancer diagnosis, whole-slide image (WSI) prediction is essential for patient prognosis, and multiple instance learning (MIL) has been implemented to handle the giga-pixel size of WSI. As MIL frameworks rely on patch-level feature aggregation, this work aims to compare the performance of various feature extractors developed under different pretraining strategies for cancer subtyping on WSI under a MIL framework. Results demonstrate the ability of foundation models to surpass ImageNet-pretrained models for the prediction of six skin cancer subtypes ## Recorded benchmark results A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage. ## Original sources and implementation [Original paper]() [PDF]()