# TAI-GAN: Temporally and Anatomically Informed GAN for early-to-late frame conversion in dynamic cardiac PET motion correction

Source: [TAI-GAN: Temporally and Anatomically Informed GAN for early-to-late frame conversion in dynamic cardiac PET motion correction](<https://www.sota2.com/research/paper/68fa705f1e209131cea4aa9a>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-26T01:40:08.455Z

Authors: Xueqi Guo, Luyao Shi, Xiongchao Chen, Bo Zhou, Qiong Liu, Huidong Xie, Yi-Hwa Liu, Richard Palyo, Edward J. Miller, Albert J. Sinusas, Bruce Spottiswoode, Chi Liu, Nicha C. Dvornek

Published: 2023-08-23T21:51:24.000Z

## Abstract

The rapid tracer kinetics of rubidium-82 ($^{82}$Rb) and high variation of cross-frame distribution in dynamic cardiac positron emission tomography (PET) raise significant challenges for inter-frame motion correction, particularly for the early frames where conventional intensity-based image registration techniques are not applicable. Alternatively, a promising approach utilizes generative methods to handle the tracer distribution changes to assist existing registration methods. To improve frame-wise registration and parametric quantification, we propose a Temporally and Anatomically Informed Generative Adversarial Network (TAI-GAN) to transform the early frames into the late reference frame using an all-to-one mapping. Specifically, a feature-wise linear modulation layer encodes channel-wise parameters generated from temporal tracer kinetics information, and rough cardiac segmentations with local shifts serve as the anatomical information. We validated our proposed method on a clinical $^{82}$Rb PET dataset and found that our TAI-GAN can produce converted early frames with high image quality, comparable to the real reference frames. After TAI-GAN conversion, motion estimation accuracy and clinical myocardial blood flow (MBF) quantification were improved compared to using the original frames. Our code is published at https://github.com/gxq1998/TAI-GAN.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/2308.12443>)

[PDF](<https://arxiv.org/pdf/2308.12443.pdf>)