# Mix-up Self-Supervised Learning for Contrast-agnostic Applications Source: [Mix-up Self-Supervised Learning for Contrast-agnostic Applications]() Collection index: [llms.txt]() Data updated: 2025-10-27T06:14:32.298Z Authors: Yichen Zhang, Yifang Yin, Ying Zhang, Roger Zimmermann Published: 2022-04-02T16:58:36.000Z ## Abstract Contrastive self-supervised learning has attracted significant research attention recently. It learns effective visual representations from unlabeled data by embedding augmented views of the same image close to each other while pushing away embeddings of different images. Despite its great success on ImageNet classification, COCO object detection, etc., its performance degrades on contrast-agnostic applications, e.g., medical image classification, where all images are visually similar to each other. This creates difficulties in optimizing the embedding space as the distance between images is rather small. To solve this issue, we present the first mix-up self-supervised learning framework for contrast-agnostic applications. We address the low variance across images based on cross-domain mix-up and build the pretext task based on two synergistic objectives: image reconstruction and transparency prediction. Experimental results on two benchmark datasets validate the effectiveness of our method, where an improvement of 2.5% ~ 7.4% in top-1 accuracy was obtained compared to existing self-supervised learning methods. ## Recorded benchmark results A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage. ## Original sources and implementation [Original paper]() [PDF]()