# Differentially private federated deep learning for multi-site medical image segmentation Source: [Differentially private federated deep learning for multi-site medical image segmentation]() Collection index: [llms.txt]() Data updated: 2025-10-25T23:22:37.170Z Authors: Alexander Ziller, Dmitrii Usynin, Nicolas Remerscheid, Moritz Knolle, Marcus Makowski, Rickmer Braren, Daniel Rueckert, Georgios Kaissis Published: 2021-07-06T12:57:32.000Z ## Abstract Collaborative machine learning techniques such as federated learning (FL) enable the training of models on effectively larger datasets without data transfer. Recent initiatives have demonstrated that segmentation models trained with FL can achieve performance similar to locally trained models. However, FL is not a fully privacy-preserving technique and privacy-centred attacks can disclose confidential patient data. Thus, supplementing FL with privacy-enhancing technologies (PTs) such as differential privacy (DP) is a requirement for clinical applications in a multi-institutional setting. The application of PTs to FL in medical imaging and the trade-offs between privacy guarantees and model utility, the ramifications on training performance and the susceptibility of the final models to attacks have not yet been conclusively investigated. Here we demonstrate the first application of differentially private gradient descent-based FL on the task of semantic segmentation in computed tomography. We find that high segmentation performance is possible under strong privacy guarantees with an acceptable training time penalty. We furthermore demonstrate the first successful gradient-based model inversion attack on a semantic segmentation model and show that the application of DP prevents it from divulging sensitive image features. ## Recorded benchmark results A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage. ## Original sources and implementation [Original paper]() [PDF]()