# Label Super Resolution with Inter-Instance Loss Source: [Label Super Resolution with Inter-Instance Loss]() Collection index: [llms.txt]() Data updated: 2025-10-25T22:00:21.133Z Authors: Maozheng Zhao, Le Hou, Han Le, Dimitris Samaras, Nebojsa Jojic, Danielle Fassler, Tahsin Kurc, Rajarsi Gupta, Kolya Malkin, Shroyer Kenneth, Joel Saltz Published: 2019-04-09T02:35:03.000Z ## Abstract For the task of semantic segmentation, high-resolution (pixel-level) ground truth is very expensive to collect, especially for high resolution images such as gigapixel pathology images. On the other hand, collecting low resolution labels (labels for a block of pixels) for these high resolution images is much more cost efficient. Conventional methods trained on these low-resolution labels are only capable of giving low-resolution predictions. The existing state-of-the-art label super resolution (LSR) method is capable of predicting high resolution labels, using only low-resolution supervision, given the joint distribution between low resolution and high resolution labels. However, it does not consider the inter-instance variance which is crucial in the ideal mathematical formulation. In this work, we propose a novel loss function modeling the inter-instance variance. We test our method on a real world application: infiltrating breast cancer region segmentation in histopathology slides. Experimental results show the effectiveness of our method. ## Recorded benchmark results A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage. ## Original sources and implementation [Original paper]() [PDF]()