# Synchronized Pivots

Source: [Synchronized Pivots](<https://www.sota2.com/research/paper/68fa5f001e209131ce9e6cff>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-25T19:05:52.386Z

Authors: J. C. Phillips

Published: 2020-03-22T15:16:08.000Z

## Abstract

Thermodynamic profiles, based on bioinformatic hydropathicity scales and membrane-fitted sliding windows, exhibit accurately level sets of hydrophobic peaks or valleys in the constant fragment Fc of monoclonal antibodies. These sets provide a roadmap for selected short regions where a few directed amino acid mutations could produce either accelerated antibody kinetics or increased stability. These profiles may reveal dramatic differences in antibody activity

## Recorded benchmark results

A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage.

## Original sources and implementation

[Original paper](<https://arxiv.org/abs/2003.12441>)

[PDF](<https://arxiv.org/pdf/2003.12441.pdf>)