# A stochastic modeling framework for single cell migration: coupling contractility and focal adhesions

Source: [A stochastic modeling framework for single cell migration: coupling contractility and focal adhesions](<https://www.sota2.com/research/paper/68fa5eee1e209131ce9e6550>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-25T19:03:51.947Z

Authors: Aydar Uatay

Published: 2018-10-26T17:35:39.000Z

## Abstract

The interaction of the actin cytoskeleton with cell-substrate adhesions is necessary for cell migration. While the trajectories of motile cells have a stochastic character, investigations of cell motility mechanisms rarely elaborate on the origins of the observed randomness. Here, guided by a few fundamental attributes of cell motility, we construct a minimal stochastic cell migration model from ground-up. The resulting model couples a deterministic actomyosin contractility mechanism with stochastic cell-substrate adhesion kinetics, and yields a well-defined piecewise deterministic process. Numerical simulations reproduce several experimentally observed results, including anomalous diffusion, tactic migration, and contact guidance. This work provides a basis for the development of cell-cell collision and population migration models.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/1810.11435>)

[PDF](<https://arxiv.org/pdf/1810.11435.pdf>)