# Stochastic kinetics of the circular gene hypothesis: feedback effects and protein fluctuations

Source: [Stochastic kinetics of the circular gene hypothesis: feedback effects and protein fluctuations](<https://www.sota2.com/research/paper/68fa5ee21e209131ce9e6089>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-25T19:02:51.915Z

Authors: Raoul R. Wadhwa, Laszlo Zalanyi, Judit Szente, Laszlo Negyessy, Peter Erdi

Published: 2015-01-12T23:18:14.000Z

## Abstract

Stochastic kinetic models of genetic expression are able to describe protein fluctuations. A comparative study of the canonical and a feedback model is given here by using stochastic simulation methods. The feedback model is skeleton model implementation of the circular gene hypothesis, which suggests the interaction between the synthesis and degradation of mRNA. Qualitative and quantitative changes in the shape and in the numerical characteristics of the stationary distributions suggest that more combined experimental and theoretical studies should be done to uncover the details of the kinetic mechanism of gene expression.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/1501.03359>)

[PDF](<https://arxiv.org/pdf/1501.03359.pdf>)