# G protein-coupled receptor-mediated calcium signaling in astrocytes

Source: [G protein-coupled receptor-mediated calcium signaling in astrocytes](<https://www.sota2.com/research/paper/68fa5ed81e209131ce9e597c>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-27T05:43:11.176Z

Authors: Maurizio De Pitt\\\`a, Eshel Ben-Jacob, Hugues Berry

Published: 2018-01-20T00:15:08.000Z

## Abstract

Astrocytes express a large variety of G~protein-coupled receptors (GPCRs) which mediate the transduction of extracellular signals into intracellular calcium responses. This transduction is provided by a complex network of biochemical reactions which mobilizes a wealth of possible calcium-mobilizing second messenger molecules. Inositol 1,4,5-trisphosphate is probably the best known of these molecules whose enzymes for its production and degradation are nonetheless calcium-dependent. We present a biophysical modeling approach based on the assumption of Michaelis-Menten enzyme kinetics, to effectively describe GPCR-mediated astrocytic calcium signals. Our model is then used to study different mechanisms at play in stimulus encoding by shape and frequency of calcium oscillations in astrocytes.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/1801.06606>)

[PDF](<https://arxiv.org/pdf/1801.06606.pdf>)