# The dose-dense principle in chemotherapy

Source: [The dose-dense principle in chemotherapy](<https://www.sota2.com/research/paper/68fa5ed01e209131ce9e5689>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-25T18:59:50.096Z

Authors: Alvaro G. Lopez, Kelly C. Iarosz, Antonio M. Batista, Jesus M. Seoane, Ricardo L. Viana, Miguel A. F. Sanjuan

Published: 2017-03-16T14:38:03.000Z

## Abstract

Chemotherapy is a class of cancer treatment that uses drugs to kill cancer cells. A typical chemotherapeutic protocol consists of several drugs delivered in cycles of three weeks. We present mathematical analyses demonstrating the existence of a maximum time between cycles of chemotherapy for a protocol to be effective. A mathematical equation is derived, which relates such a maximum time with the variables that govern the kinetics of the tumor and those characterizing the chemotherapeutic treatment. Our results suggest that there are compelling arguments supporting the use of dose-dense protocols. Finally, we discuss the limitations of these protocols and suggest an alternative.

## Recorded benchmark results

A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage.

## Original sources and implementation

[Original paper](<https://arxiv.org/abs/1703.06071>)

[PDF](<https://arxiv.org/pdf/1703.06071.pdf>)