# Comment on "Regularizing capacity of metabolic networks"

Source: [Comment on "Regularizing capacity of metabolic networks"](<https://www.sota2.com/research/paper/68fa5e911e209131ce9e381b>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-28T13:56:18.430Z

Authors: Petter Holme, Mikael Huss

Published: 2007-05-28T18:50:56.000Z

## Abstract

In a recent paper, Marr, Muller-Linow and Hutt \[Phys. Rev. E 75, 041917 (2007)\] investigate an artificial dynamic system on metabolic networks. They find a less complex time evolution of this dynamic system in real networks, compared to networks of reference models. The authors argue that this suggests that metabolic network structure is a major factor behind the stability of biochemical steady states. We reanalyze the same kind of data using a dynamic system modeling actual reaction kinetics. The conclusions about stability, from our analysis, are inconsistent with those of Marr et al. We argue that this issue calls for a more detailed type of modeling.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/0705.4084>)

[PDF](<https://arxiv.org/pdf/0705.4084.pdf>)