# Sequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation

Source: [Sequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation](<https://www.sota2.com/research/paper/68fa5e8b1e209131ce9e3430>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-25T18:51:47.974Z

Authors: Vincent Lemaire, Chiu Fan Lee, Jinzhi Lei, Raphael Metivier, Leon Glass

Published: 2006-05-30T16:14:02.000Z

## Abstract

In human cells, estrogenic signals induce cyclical association and dissociation of specific proteins with the DNA in order to activate transcription of estrogen-responsive genes. These oscillations can be modeled by assuming a large number of sequential reactions represented by linear kinetics with random kinetic rates. Application of the model to experimental data predicts robust binding sequences in which proteins associate with the DNA at several different phases of the oscillation. Our methods circumvent the need to derive detailed kinetic graphs, and are applicable to other oscillatory biological processes involving a large number of sequential steps.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/q-bio/0605049>)

[PDF](<https://arxiv.org/pdf/q-bio/0605049.pdf>)