# Quantitative modeling and simulation of biochemical processes in the human body

Source: [Quantitative modeling and simulation of biochemical processes in the human body](<https://www.sota2.com/research/paper/68fa5aab1e209131ce9c1b50>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-25T16:37:49.538Z

Authors: Jacob Bendsen, Peter Emil Carstensen, Asbj{\\o}rn Thode Reenberg, Tobias K. S. Ritschel, John Bagterp J{\\o}rgensen

Published: 2023-07-30T08:25:53.000Z

## Abstract

We present a whole-body model of human metabolism that utilizes a system of organs and blood vessels to simulate the enzymatic reactions. The model focuses on key organs, including the brain, heart and lungs, liver, gut, and kidney, as well as muscle and adipose tissue. The model equations are formulated using stoichiometry and Michaelis-Menten kinetics to describe the enzymatic reactions. We demonstrate how the model can be used to simulate the effects of prolonged fasting and intermittent fasting on selected metabolite concentrations and glucose flux. Furthermore, by simulating intermittent fasting the effect on the carbohydrate, the protein and the lipid storage is examined. We propose this method as a simple and intuitive approach for modeling the human metabolism, which is general, systematic and easy to incorporate. This could have potential applications in PK/PD drug development and in understanding metabolic disorders.

## Recorded benchmark results

A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage.

## Original sources and implementation

[Original paper](<https://arxiv.org/abs/2307.16167>)

[PDF](<https://arxiv.org/pdf/2307.16167.pdf>)