# Bimodality, prion aggregates infectivity and prediction of strain phenomenon Source: [Bimodality, prion aggregates infectivity and prediction of strain phenomenon]() Collection index: [llms.txt]() Data updated: 2025-10-28T13:55:06.999Z Authors: Vincent Calvez, Natacha Lenuzza, Dietmar Oelz, Jean-Philippe Deslys, Pascal Laurent, Franck Mouthon, Beno\\^it Perthame Published: 2008-02-14T14:31:32.000Z ## Abstract We consider a model for the polymerization (fragmentation) process involved in infectious prion self-replication and study both its dynamics and non-zero steady state. We address several issues. Firstly, we give conditions leading to size repartitions of PrPsc aggregates that exhibit bimodal distributions, as indicated by recent experimental studies of prion aggregates distribution. Secondly, we show stability results for this steady state for general coefficients where reduction to a system of differential equations is not possible. We use a duality method based on recent ideas developed for population models. These results underline the potential influence of the amyloid precursor production rate in promoting amyloidogenic diseases. Finally, we numerically investigate the influence of different parameters of the model on PrPsc accumulation kinetics, in the aim to study specific features of prion strains. ## Recorded benchmark results A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage. ## Original sources and implementation [Original paper]() [PDF]()