# Multi-contrast laser endoscopy for in vivo gastrointestinal imaging

Source: [Multi-contrast laser endoscopy for in vivo gastrointestinal imaging](<https://www.sota2.com/research/paper/68fa4ab31e209131ce940804>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2026-05-08T05:00:04.262Z

Authors: Taylor L. Bobrow, Mayank Golhar, Suchapa Arayakarnkul, Anthony A. Song, Saowanee Ngamruengphong, Nicholas J. Durr

Published: 2025-05-15T16:47:24.000Z

## Abstract

White light endoscopy is the clinical gold standard for detecting diseases in the gastrointestinal tract. Most applications involve identifying visual abnormalities in tissue color, texture, and shape. Unfortunately, the contrast of these features is often subtle, causing many clinically relevant cases to go undetected. To overcome this challenge, we introduce Multi-contrast Laser Endoscopy (MLE): a platform for widefield clinical imaging with rapidly tunable spectral, coherent, and directional illumination. We demonstrate three capabilities of MLE: enhancing tissue chromophore contrast with multispectral diffuse reflectance, quantifying blood flow using laser speckle contrast imaging, and characterizing mucosal topography using photometric stereo. We validate MLE with benchtop models, then demonstrate MLE in vivo during clinical colonoscopies. MLE images from 31 polyps demonstrate an approximate three-fold improvement in contrast and a five-fold improvement in color difference compared to white light and narrow band imaging. With the ability to reveal multiple complementary types of tissue contrast while seamlessly integrating into the clinical environment, MLE shows promise as an investigative tool to improve gastrointestinal imaging.

## Recorded benchmark results

A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage.

- [Paired RMS contrast comparison on Clinical colonoscopy samples](<https://www.sota2.com/research/sota/paired-rms-contrast-comparison-on-clinical-colonoscopy-samples.md>): Paired RMS contrast comparison; Clinical colonoscopy samples; Delta Mu (Δμ): 0.159.

- [Color Difference Comparison on Clinical endoscopy modalities dataset](<https://www.sota2.com/research/sota/color-difference-comparison-on-clinical-endoscopy-modalities-dataset.md>): Color Difference Comparison; Clinical endoscopy modalities dataset; Delta mu: not recorded.

## Original sources and implementation

[Original paper](<https://arxiv.org/abs/2505.10492>)

[PDF](<https://arxiv.org/pdf/2505.10492.pdf>)