# Poissonian cellular Potts models reveal nonequilibrium kinetics of cell sorting

Source: [Poissonian cellular Potts models reveal nonequilibrium kinetics of cell sorting](<https://www.sota2.com/research/paper/68fa4aa01e209131ce940088>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-25T07:56:47.958Z

Authors: Roman Belousov, Sabrina Savino, Prachiti Moghe, Takashi Hiiragi, Lamberto Rondoni, Anna Erzberger

Published: 2023-06-07T14:03:17.000Z

## Abstract

Cellular Potts models are broadly applied across developmental biology and cancer research. We overcome limitations of the traditional approach, which reinterprets a modified Metropolis sampling as ad hoc dynamics, by introducing a physical timescale through Poissonian kinetics and by applying principles of stochastic thermodynamics to separate thermal and relaxation effects from athermal noise and nonconservative forces. Our method accurately describes cell-sorting dynamics in mouse-embryo development and identifies the distinct contributions of nonequilibrium processes, e.g. cell growth and active fluctuations.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/2306.04443>)

[PDF](<https://arxiv.org/pdf/2306.04443.pdf>)