# Pt nanoparticles dispersed in a metal-organic framework as peroxidase mimics for colorimetric detection of GSH

Source: [Pt nanoparticles dispersed in a metal-organic framework as peroxidase mimics for colorimetric detection of GSH](<https://www.sota2.com/research/paper/68fa47201e209131ce925ad2>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-25T06:10:12.783Z

Authors: Yanzheng Shu, Yanwei Chen, Guiye Shan

Published: 2024-06-03T05:26:37.000Z

## Abstract

Metal-organic skeleton materials have been widely used in catalysis with their porous structure and adsorption properties. Precious metal nanoparticles have good catalytic properties. If the noble metal nanoparticles are adsorbed on the MOFs surface, the active sites can be increased and the catalytic effect of the materials can be greatly improved. We successfully synthesized Pt@ZIF-8 in two steps, the average particle size of Pt nanoparticles is about 3 nm. Pt@ZIF-8 possesses peroxidase activity and can oxidize colorless TMB to oxTMB in the presence of hydrogen peroxide. The peroxide-like nature of Pt@ZIF-8 is consistent with Michaelis-Menten kinetics. Glutathione is a reducing substance that reduces blue oxTMB to colorless oxTMB. This colorimetric method achieves a simple, sensitive and intuitive detection of glutathione. The detection limit of this experiment is low, which is promising in biomolecular detection.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/2406.01004>)

[PDF](<https://arxiv.org/pdf/2406.01004.pdf>)