# Ion channels in critical membranes: clustering, cooperativity, and memory effects

Source: [Ion channels in critical membranes: clustering, cooperativity, and memory effects](<https://www.sota2.com/research/paper/68fa46281e209131ce91e0c4>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-28T13:54:44.683Z

Authors: Antonio Suma, Daniel Sigg, Seamus Gallagher, Giuseppe Gonnella, Vincenzo Carnevale

Published: 2024-01-15T13:03:58.000Z

## Abstract

Much progress has been made in elucidating the inner workings of voltage-gated ion channels, but less understood is the influence of lipid rafts on gating kinetics. Here we propose that state-dependent channel affinity for different lipid species provides a unified explanation for the experimentally observed behaviors of clustering, cooperativity, and hysteresis. We develop models of diffusing lipids and channels engaged in Ising-like interactions to investigate the collective behaviors driven by raft formation in critical membranes close to the demixing transition. The model channels demonstrate lipid-mediated long-range interactions, activation curve steepening, and long-term memory in ionic currents. These behaviors likely play a role in channel-mediated cellular signaling and suggest a universal mechanism for self-organization of biomolecular assemblies.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/2401.07660>)

[PDF](<https://arxiv.org/pdf/2401.07660.pdf>)