# Repair kinetics of DSB-foci induced by proton and helium ion microbeams of different energies

Source: [Repair kinetics of DSB-foci induced by proton and helium ion microbeams of different energies](<https://www.sota2.com/research/paper/68fa44bb1e209131ce9137a9>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-25T04:56:52.982Z

Authors: Ana Belchior, Jo\\~ao F. Canhoto, Ulrich Giesen, Frank Langner, Hans Rabus, Reinhard Schulte (5) \_\_INSTITUTION\_6\_\_ Centro de Ci\\^encias e Tecnologias Nucleares, Instituto Superior T\\'ecnico, Universidade de Lisboa, Estrada Nacional 10 (2) Departamento de F\\'isica, Instituto Superior T\\'ecnico, Universidade de Lisboa (3) Physikalisch-Technische Bundesanstalt, 38116 Braunschweig, Germany (4) Physikalisch-Technische Bundesanstalt, 10587 Berlin, Germany (5) Division of Biomedical Engineering Sciences, Loma Linda University, United States of America)

Published: 2022-06-17T19:24:26.000Z

## Abstract

In this work, the induction and repair of radiation-induced 53BP1 foci were studied in human umbilical vein endothelial cells irradiated at the PTB microbeam with protons and {\\alpha}-particles of different energies. The data were analyzed in terms of the mean number of 53BP1 foci induced by the different ion beams. The number of 53BP1 foci found at different times post-irradiation suggests that the disappearance of foci follows first order kinetics. The mean number of initially produced foci shows the expected increase with LET. The most interesting finding of this work is that the absolute number of persistent foci increases with LET but not their fraction. Furthermore, protons seem to produce more persistent foci as compared to {\\alpha}-particles of even higher LET. This may be seen as experimental evidence that protons may be more effective in producing severe DNA lesions, as was already shown in other work, and that LET may not be the best suited parameter to characterize radiation quality

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/2206.08981>)

[PDF](<https://arxiv.org/pdf/2206.08981.pdf>)