# Precision of protein thermometry

Source: [Precision of protein thermometry](<https://www.sota2.com/research/paper/68fa3ffd1e209131ce8efd0e>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-25T02:32:28.061Z

Authors: Michael Vennettilli, Soutick Saha, Ushasi Roy, Andrew Mugler

Published: 2020-12-05T01:22:34.000Z

## Abstract

Temperature sensing is a ubiquitous cell behavior, but the fundamental limits to the precision of temperature sensing are poorly understood. Unlike in chemical concentration sensing, the precision of temperature sensing is not limited by extrinsic fluctuations in the temperature field itself. Instead, we find that precision is limited by the intrinsic copy number, turnover, and binding kinetics of temperature-sensitive proteins. Developing a model based on the canonical TlpA protein, we find that a cell can estimate temperature to within 2%. We compare this prediction with in vivo data on temperature sensing in bacteria.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/2012.02918>)

[PDF](<https://arxiv.org/pdf/2012.02918.pdf>)