# Modelling drug delivery from multiple emulsions

Source: [Modelling drug delivery from multiple emulsions](<https://www.sota2.com/research/paper/68fa3cb21e209131ce8dcb48>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-25T01:16:58.050Z

Authors: G. Pontrelli, E.J. Carr, A. Tiribocchi, S. Succi

Published: 2020-04-09T14:56:43.000Z

## Abstract

We present a mechanistic model of drug release from a multiple emulsion into an external surrounding fluid. We consider a single multi-layer droplet where the drug kinetics are described by a pure diffusive process through different liquid shells. The multi-layer problem is described by a system of diffusion equations coupled via interlayer conditions imposing continuity of drug concentration and flux. Mass resistance is imposed at the outer boundary through the application of a surfactant at the external surface of the droplet. The two-dimensional problem is solved numerically by finite volume discretization. Concentration profiles and drug release curves are presented for three typical round-shaped (circle, ellipse and bullet) droplets and the dependency of the solution on the mass transfer coefficient at the surface analyzed. The main result shows a reduced release time for an increased elongation of the droplets.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/2004.05921>)

[PDF](<https://arxiv.org/pdf/2004.05921.pdf>)