# A topological study of protein folding kinetics

Source: [A topological study of protein folding kinetics](<https://www.sota2.com/research/paper/68fa3aa51e209131ce8cc865>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-25T00:11:48.685Z

Authors: E. Panagiotou, K. W. Plaxco

Published: 2018-12-03T13:10:58.000Z

## Abstract

Focusing on a small set of proteins that i) fold in a concerted, all-or-none fashion and ii) do not contain knots or slipknots, we show that the Gauss linking integral, the torsion and the number of sequence-distant contacts provide information regarding the folding rate. Our results suggest that the global topology/geometry of the proteins shifts from right-handed to left-handed with decreasing folding rate, and that this topological change is associated with an increase in the number of more sequence-distant contacts.

## Recorded benchmark results

A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage.

## Original sources and implementation

[Original paper](<https://arxiv.org/abs/1812.08721>)

[PDF](<https://arxiv.org/pdf/1812.08721.pdf>)