# Kinetic signature of cooperativity in the irreversible collapse of a polymer

Source: [Kinetic signature of cooperativity in the irreversible collapse of a polymer](<https://www.sota2.com/research/paper/68fa382a1e209131ce8b84e3>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-24T22:49:31.368Z

Authors: Vittore F. Scolari, Guillaume Mercy, Romain Koszul, Annick Lesne, Julien Mozziconacci

Published: 2018-04-11T17:09:08.000Z

## Abstract

We investigate the kinetics of a polymer collapse due to the formation of irreversible crosslinks between its monomers. Using the contact probability $P(s)$ as a scale-dependent order parameter depending on the chemical distance $s$, our simulations show the emergence of a cooperative pearling instability. Namely, the polymer undergoes a sharp conformational transition to a set of absorbing states characterized by a length scale $\\xi$ corresponding to the mean pearl size. This length and the transition time depend on the polymer equilibrium dynamics and the crosslinking rate. We confirm experimentally this transition using a DNA conformation capture experiment in yeast.

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/1804.04099>)

[PDF](<https://arxiv.org/pdf/1804.04099.pdf>)