# Kinetics and thermodynamics of DNA polymerases with exonuclease proofreading

Source: [Kinetics and thermodynamics of DNA polymerases with exonuclease proofreading](<https://www.sota2.com/research/paper/68fa37011e209131ce8ae9e0>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-24T22:08:30.173Z

Authors: Pierre Gaspard

Published: 2016-04-09T12:22:16.000Z

## Abstract

Kinetic theory and thermodynamics are applied to DNA polymerases with exonuclease activity, taking into account the dependence of the rates on the previously incorportated nucleotide. The replication fidelity is shown to increase significantly thanks to this dependence at the basis of the mechanism of exonuclease proofreading. In particular, this dependence can provide up to a hundred-fold lowering of the error probability under physiological conditions. Theory is compared with numerical simulations for the DNA polymerases of T7 viruses and human mitochondria.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/1604.02554>)

[PDF](<https://arxiv.org/pdf/1604.02554.pdf>)