# Enzyme kinetics: A note on negative reaction constants in Lineweaver-Burk plots

Source: [Enzyme kinetics: A note on negative reaction constants in Lineweaver-Burk plots](<https://www.sota2.com/research/paper/68fa369a1e209131ce8ab62e>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-24T21:55:12.419Z

Authors: Sharmistha Dhatt, Kamal Bhattacharyya

Published: 2017-10-23T08:00:04.000Z

## Abstract

Reaction constants in traditional Michaelis-Menten type enzyme kinetics are most often determined through a linear Lineweaver-Burk plot. While such a graphical plot is sometimes good to achieve the end, it is always better to go for a few numerical tests that can assess the quality of the data set being used and hence offer more reliable measures of the quantities sought, furnishing along with appropriate error estimates. In this context, we specifically highlight how cases may appear with negative reaction constants and explore the origin of such bizarre findings.

## Recorded benchmark results

A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage.

## Original sources and implementation

[Original paper](<https://arxiv.org/abs/1710.08131>)

[PDF](<https://arxiv.org/pdf/1710.08131.pdf>)