# The role of the peptides in enzymes at the origin of live

Source: [The role of the peptides in enzymes at the origin of live](<https://www.sota2.com/research/paper/68fa35371e209131ce89f945>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-24T21:08:17.864Z

Authors: S{\\o}ren Toxvaerd

Published: 2017-02-06T14:15:01.000Z

## Abstract

The peptides in biosystems are homochiral polymers of L-amino acids, but razemisate slowly by an active isomerization kinetics. The chemical reactions in biosystems are, however, reversible and what racemisates the peptides at the water activity in the biosystems can ensure homochirality at a smaller activity. Here we show by a thermodynamics analysis and by comprehensive Molecular Dynamics simulations of models of peptides, that the isomerization kinetics racemisates the peptides at a high water activity in agreement with experimental observations of aging of peptides , but enhances homochirality at a smaller water activity. The hydrophobic core of the peptide in an enzyme can ensure homochirality at a low water activity, and thus the establishment of homochirality at the origin of life and ageing of peptides and dead of biosystems might be strongly connected.

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/1702.01623>)

[PDF](<https://arxiv.org/pdf/1702.01623.pdf>)