# Diffusive Dynamics of the Reaction Coordinate for Protein Folding Funnels

Source: [Diffusive Dynamics of the Reaction Coordinate for Protein Folding Funnels](<https://www.sota2.com/research/paper/68fa342a1e209131ce896768>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-24T20:30:18.930Z

Authors: N. D. Socci, J. N. Onuchic, P. G. Wolynes

Published: 1996-01-21T01:22:31.000Z

## Abstract

The quantitative description of model protein folding kinetics using a diffusive collective reaction coordinate is examined. Direct folding kinetics, diffusional coefficients and free energy profiles are determined from Monte Carlo simulations of a 27-mer, 3 letter code lattice model, which corresponds roughly to a small helical protein. Analytic folding calculations, using simple diffusive rate theory, agree extremely well with the full simulation results. Folding in this system is best seen as a diffusive, funnel-like process.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/cond-mat/9601091>)

[PDF](<https://arxiv.org/pdf/cond-mat/9601091.pdf>)