# Statistical mechanics of the Huxley-Simmons model

Source: [Statistical mechanics of the Huxley-Simmons model](<https://www.sota2.com/research/paper/68fa33a01e209131ce891ebe>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-24T20:11:50.938Z

Authors: M Caruel, L Truskinovsky

Published: 2016-05-26T14:53:04.000Z

## Abstract

The chemomechanical model of Huxley and Simmons (HS) \[A. F. Huxley and R. M. Simmons, Nature 233, 533 (1971)\] provides a paradigmatic description of mechanically induced collective conformational changes relevant in a variety of biological contexts, from muscles power-stroke and hair cell gating to integrin binding and hairpin unzipping. We develop a statistical mechanical perspective on the HS model by exploiting a formal analogy with a paramagnetic Ising model. We first study the equilibrium HS model with a finite number of elements and compute explicitly its mechanical and thermal properties. To model kinetics, we derive a master equation and solve it for several loading protocols. The developed formalism is applicable to a broad range of allosteric systems with mean-field interactions.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/1605.08314>)

[PDF](<https://arxiv.org/pdf/1605.08314.pdf>)