# Kinetics of self-assembly via facilitated diffusion: formation of the transcription complex Source: [Kinetics of self-assembly via facilitated diffusion: formation of the transcription complex]() Collection index: [llms.txt]() Data updated: 2025-10-24T19:32:03.028Z Authors: Ziya Kalay Published: 2015-04-24T09:55:30.000Z ## Abstract We present an analytically solvable model for self-assembly of a molecular complex on a filament. The process is driven by a seed molecule that undergoes facilitated diffusion, which is a search strategy that combines diffusion in three-dimensions and one-dimension. Our study is motivated by single molecule level observations revealing the dynamics of transcription factors that bind to the DNA at early stages of transcription. We calculate the probability that a complex made up of a given number of molecules is completely formed, as well as the distribution of completion times, upon the binding of a seed molecule at a target site on the filament (without explicitly modeling the three-dimensional diffusion that precedes binding). We compare two different mechanisms of assembly where molecules bind in sequential and random order. Our results indicate that while the probability of completion is greater for random binding, the completion time scales exponentially with the size of the complex; in contrast, it scales as a power-law or slower for sequential binding, asymptotically. Furthermore, we provide model predictions for the dissociation and residence times of the seed molecule, which are observables accessible in single molecule tracking experiments. ## Recorded benchmark results A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage. ## Original sources and implementation [Original paper]() [PDF]()