# Distance matters: the impact of gene proximity in bacterial gene regulation

Source: [Distance matters: the impact of gene proximity in bacterial gene regulation](<https://www.sota2.com/research/paper/68fa30d01e209131ce879077>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-24T18:28:26.813Z

Authors: Otto Pulkkinen, Ralf Metzler

Published: 2013-05-13T05:35:32.000Z

## Abstract

Following recent discoveries of colocalization of downstream-regulating genes in living cells, the impact of the spatial distance between such genes on the kinetics of gene product formation is increasingly recognized. We here show from analytical and numerical analysis that the distance between a transcription factor (TF) gene and its target gene drastically affects the speed and reliability of transcriptional regulation in bacterial cells. For an explicit model system we develop a general theory for the interactions between a TF and a transcription unit. The observed variations in regulation efficiency are linked to the magnitude of the variation of the TF concentration peaks as a function of the binding site distance from the signal source. Our results support the role of rapid binding site search for gene colocalization and emphasize the role of local concentration differences.

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/1305.2677>)

[PDF](<https://arxiv.org/pdf/1305.2677.pdf>)