# Stochastic force generation by small ensembles of myosin II motors

Source: [Stochastic force generation by small ensembles of myosin II motors](<https://www.sota2.com/research/paper/68fa303b1e209131ce8734bc>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-24T18:03:42.712Z

Authors: Thorsten Erdmann, Ulrich S. Schwarz

Published: 2012-02-14T13:50:48.000Z

## Abstract

Forces in the actin cytoskeleton are generated by small groups of non-processive myosin II motors for which stochastic effects are highly relevant. Using a crossbridge model with the assumptions of fast powerstroke kinetics and equal load sharing between equivalent states, we derive a one-step master equation for the activity of a finite-sized ensemble of mechanically coupled myosin II motors. For constant external load, this approach yields analytical results for duty ratio and force-velocity relation as a function of ensemble size. We find that stochastic effects cannot be neglected for ensemble sizes below 15. The one-step master equation can be used also for efficient computer simulations with linear elastic external load and reveals the sequence of build-up of force and ensemble rupture that is characteristic for reconstituted actomyosin contractility.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/1202.3038>)

[PDF](<https://arxiv.org/pdf/1202.3038.pdf>)