# A simple theory of protein folding kinetics

Source: [A simple theory of protein folding kinetics](<https://www.sota2.com/research/paper/68fa2f631e209131ce86b6e9>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-24T17:30:52.117Z

Authors: Vijay S. Pande

Published: 2010-07-02T08:08:52.000Z

## Abstract

We present a simple model of protein folding dynamics that captures key qualitative elements recently seen in all-atom simulations. The goals of this theory are to serve as a simple formalism for gaining deeper insight into the physical properties seen in detailed simulations as well as to serve as a model to easily compare why these simulations suggest a different kinetic mechanism than previous simple models. Specifically, we find that non-native contacts play a key role in determining the mechanism, which can shift dramatically as the energetic strength of non-native interactions is changed. For protein-like non-native interactions, our model finds that the native state is a kinetic hub, connecting the strength of relevant interactions directly to the nature of folding kinetics.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/1007.0315>)

[PDF](<https://arxiv.org/pdf/1007.0315.pdf>)