# Competition between monomeric and dimeric crystals in schematic models for globular proteins

Source: [Competition between monomeric and dimeric crystals in schematic models for globular proteins](<https://www.sota2.com/research/paper/68fa2d2f1e209131ce85713b>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-24T15:49:33.013Z

Authors: Diana Fusco, Patrick Charbonneau

Published: 2014-03-17T21:42:12.000Z

## Abstract

Advances in experimental techniques and in theoretical models have improved our understanding of protein crystallization. But they have also left open questions regarding the protein phase behavior and self-assembly kinetics, such as why (nearly) identical crystallization conditions sometimes result in the formation of different crystal forms. Here, we develop a patchy particle model with competing sets of patches that provides a microscopic explanation of this phenomenon. We identify different regimes in which one or two crystal forms can coexist with a low-density fluid. Using analytical approximations, we extend our findings to different crystal phases, providing a general framework for treating protein crystallization when multiple crystal forms compete. Our results also suggest different experimental routes for targeting a specific crystal form, and for reducing the dynamical competition between the two forms, thus facilitating protein crystal assembly.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/1403.4277>)

[PDF](<https://arxiv.org/pdf/1403.4277.pdf>)