# DNA-Programmed Mesoscopic Architecture

Source: [DNA-Programmed Mesoscopic Architecture](<https://www.sota2.com/research/paper/68fa2ccd1e209131ce85363d>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-24T15:35:06.429Z

Authors: Jonathan D. Halverson, Alexei V. Tkachenko

Published: 2013-01-07T02:26:20.000Z

## Abstract

We study the problem of the self-assembly of nanoparticles (NPs) into finite mesoscopic structures with a programmed local morphology and complex overall shape. Our proposed building blocks are NPs directionally-functionalized with DNA. The combination of directionality and selectivity of interactions allows one to avoid unwanted metastable configurations which have been shown to lead to slow self-assembly kinetics even in much simpler systems. With numerical simulations, we show that a variety of target mesoscopic objects can be designed and self-assembled in near perfect yield. They include cubes, pyramids, boxes and even an Empire State Building model. We summarize our findings with a set of design strategies that lead to the successful self-assembly of a wide range of mesostructures.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/1301.1098>)

[PDF](<https://arxiv.org/pdf/1301.1098.pdf>)