# Quantification of noise in the bifunctionality-induced post-translational modification Source: [Quantification of noise in the bifunctionality-induced post-translational modification]() Collection index: [llms.txt]() Data updated: 2025-10-24T15:31:06.902Z Authors: Alok Kumar Maity, Arnab Bandyopadhyay, Sudip Chattopadhyay, Jyotipratim Ray Chaudhuri, Ralf Metzler, Pinaki Chaudhury, Suman K Banik Published: 2012-11-01T06:19:23.000Z ## Abstract We present a generic analytical scheme for the quantification of fluctuations due to bifunctionality-induced signal transduction within the members of bacterial two-component system. The proposed model takes into account post-translational modifications in terms of elementary phosphotransfer kinetics. Sources of fluctuations due to autophosphorylation, kinase and phosphatase activity of the sensor kinase have been considered in the model via Langevin equations, which are then solved within the framework of linear noise approximation. The resultant analytical expression of phosphorylated response regulators are then used to quantify the noise profile of biologically motivated single and branched pathways. Enhancement and reduction of noise in terms of extra phosphate outflux and influx, respectively, have been analyzed for the branched system. Furthermore, role of fluctuations of the network output in the regulation of a promoter with random activation/deactivation dynamics has been analyzed. ## Recorded benchmark results A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage. ## Original sources and implementation [Original paper]() [PDF]()